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《Chinese Journal of New Drugs》 2006-05
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A randomized and double blind positive control clinical trial of bupropion SR for the treatment of depression

CHEN Jin-dong GUO Xiao-feng XUE Zhi-min LUO Qiong LI Le-hua ZHAO Jing-ping CHEN Yuan-guang (Mental Health Institute,The Second Hospital Affiliated to Xiangya Medical College,Central South University,Changsha 41 O011,China)  
Objective:To evaluate the efficacy and safety of bupropion SR made in China in the treatment of depression.Methods:A randomized,double blind positive control clinical trial enrolled forth-eight patients with depression,who were randomized 1:1 to administer bupropion SR 300 mg or flu- oxetine 20 mg daily for 42 days.The efficacy of both treatment groups was evaluated based on the Hamil- ton Depression Scale and Clinical General Impression Scale pre- and post-treatment.Results:Compared to the baseline scores,patients experienced significant improvements in the Hamilton Depression Scale at the end of the therapy(P<0.05).The efficacy rate in both treatment groups was 86.4% and 73.9%, respectively;the p value showed no significant difference(P>0.05).Both therapies demonstrated com- mon adverse events including nausea,dizziness,dry mouth,and poor appetite.Conclusion:Bupropion SR made in China offers an effective and safe option in the treatment of depression.
【CateGory Index】: R749.4
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