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《Chinese Journal of New Drugs》 2009-14
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Preparation of berberine hydrochloride-phospholipid complex and its physic-chemical properties

ZUO ju-bo1,SHANG Jing-chuan1,2(1 College of Pharmacy,Chongqing Medical University,Chongqing 400016,China;2 Institute of Materia Medical Chongqing Medical University,Chongqing 400016,China)  
Objective:To prepare Berberine hydrochloride-phospholipid complex and investigate its physic-chemical properties.Methods:The effects of the reactive temperature,the reactive time,the concentration of reactants and the ratio of reactants on preparation were investigated using orthogonal design,and the physic-chemical properties of Berberine hydrochloride-phospholipid complex including Infrared spectra,phase-transition characteristics,and solubility were examined.Results:The optimized conditions were obtained as follows:the reactive temperature was 60 ℃,the reactive time was 3 h,the concentration of reactants was 1.5 mg·mL-1 and the ratio of Berberine hydrochloride to phospholipid was 1∶1.The change of the transformation temperature was showed in DSC spectra.The solubility of Berberine hydrochloride-phospholipid complex was improved in n-octyl alcohol.Conclusions:The optimized method to prepare Berberine hydrochloride-phospholipid complex is achieved,and its physic-chemical properties are significantly different from those of Berberine hydrochloride.
【CateGory Index】: R287
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