Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of New Drugs》 2009-14
Add to Favorite Get Latest Update

Preparation of berberine hydrochloride-phospholipid complex and its physic-chemical properties

ZUO ju-bo1,SHANG Jing-chuan1,2(1 College of Pharmacy,Chongqing Medical University,Chongqing 400016,China;2 Institute of Materia Medical Chongqing Medical University,Chongqing 400016,China)  
Objective:To prepare Berberine hydrochloride-phospholipid complex and investigate its physic-chemical properties.Methods:The effects of the reactive temperature,the reactive time,the concentration of reactants and the ratio of reactants on preparation were investigated using orthogonal design,and the physic-chemical properties of Berberine hydrochloride-phospholipid complex including Infrared spectra,phase-transition characteristics,and solubility were examined.Results:The optimized conditions were obtained as follows:the reactive temperature was 60 ℃,the reactive time was 3 h,the concentration of reactants was 1.5 mg·mL-1 and the ratio of Berberine hydrochloride to phospholipid was 1∶1.The change of the transformation temperature was showed in DSC spectra.The solubility of Berberine hydrochloride-phospholipid complex was improved in n-octyl alcohol.Conclusions:The optimized method to prepare Berberine hydrochloride-phospholipid complex is achieved,and its physic-chemical properties are significantly different from those of Berberine hydrochloride.
【CateGory Index】: R287
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 OU Jin-qiang 1 WANG Yong 2 LIU Xiang 2 HUANG Jian-hua 3 WANG Xing-guo 3(1 Excelic Food(Nanjing)Co.,Ltd.,Nanjing Jiangsu 210058;2 East Ocean Grain and Oils Industry(Zhangjiagang)Co.,Ltd.;3 Food Science and Technology,Jiangnan University);Preparation Process of Vitamin C and Soy Lecithin Compound[J];Modern Agricultural Sciences and Technology;2011-07
2 Wang Dan~(1,2),Wang Ji~(1,2),Yan Xueying~2,Kuang Haixue~2,Wang Xiangtao~1 (1.Institute of Medicinal Plant Development Office of Pharmacy,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100193,China; 2.Heilongjiang University of Chinese Medicine College of Pharmacy,Harbin 150040,China);Preparation and Characterization of Phytosomes of Total Flavonoids of Flos Daturae[J];World Science and Technology(Modernization of Traditional Chinese Medicine and Materia Medica);2010-05
3 HAN Wen-li,LU Wei,HE Dong-ping,LONG You-qi,SHANG Jing-chuan(College of Pharmaceutical Sciences,Chongqing Medical University,Chongqing 400016,China);Pharmacokinetics and Relative Bioavailability Study of Berberine Hydrochloride Phytosome in Rabbits[J];China Pharmacy;2011-17
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Lu Guoqing1,2,Zheng Jiang3,Zheng Xinchuan3,Lu Yonglin3,He Fengci1(1Division of Scientific Research Affairs,3Medical Research Center,Southwestern Hospital,Third Military Medical University,Chongqing,400038;2 Department of Clinical Pharmacy,General Hospital of Chengdu Military Command,Chengdu,Sichuan Province,610083,China);Preparation and characterization of oridonin phospholipid complex[J];Acta Academiae Medicinae Militaris Tertiae;2010-20
2 LI Yong-Min1,CHEN Xiao-Chun2,LUO Fei1,LI Gang1 1Section of Chinese Medicine and Recipe,Department of Traditional Chinese Medicine,2Department of Neurology,First Affiliated Hospital,Hebei North University,Zhangjiakou 075029,China;Effects of total ginsenoside combined with berberine on cardiac myosin heavy chain in experimental rats with chronic congestive heart failure[J];Journal of the Fourth Military Medical University;2009-14
3 Xia Haitao, An Hong, Liu Yufen, Yu Chunling (Physical Chemistry Teaching and Research Section, Institude of Chemistry and Chemical Engineering, Qiqihaer University, Qiqihaer 161006);Analysis of Soybean Phospholipids by High Performance Liquid Chromatography[J];Chinese Journal of Analytieal Chemistry;2001-09
4 LI Bao-hong 1,ZHANG Li-jian 2,DONGYE Guang-zhi 2,DENG Yi-feng 1,LIANG Nian-ci 1 (1.Key Laboratory of Natural Drugs Research and Development of Guangdong,Guangdong Medical College,Zhanjiang 524023,China;2.Center Lab of Guangdong Medical College,Zhanjiang 524023,China);Study on the solid dispersion of quercetin-PEG6000[J];West China Journal of Pharmaceutical Sciences;2004-01
5 WEI Wei,ZHAO Dong,ZHANG Zhi-Rong,GONG Tao(Key Laboratory of Drug Targeting,Ministry of Education West China School of Pharmacy,Sichuan University,Chengdu 610041,China);Study on the physico-chemical properties of hydroxycamptothecin-phospholipid complex[J];West China Journal of Pharmaceutical Sciences;2008-04
6 Gao Qiuhua Wu Qingzhi Huang Kaixun Xu Huibi;Study on the Absorption Enhancer of Insulin Sublingual Drops[J];JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY;2000-05
7 WANG Mo lin 1,AN Hong 2,CHEN Zhi qiang 1,XING Yu shang 1,TONG Bai 1,WU Xiao hui 1, WU Ping 1,TIAN Zhi ming 1,SONG Wei ming 1 (1.College of Chemical Engineering,Qiqihaer University,Qiqihaer 161006,China;2.State Key Laboratory of Fine Chemi;Technological Creation and Systematic Research of Phospholipid[J];Fine Chemicals;2001-01
8 LIU Chun, XIE Wei ,YU Feng(Research division of pharmacology, China pharmaceutical university, Nanjing 210009 China);Phytosomes - α -Diammonium glycyrrhizate phosphatidylcholine complex[J];Anti-infection Phurmacy;2004-03
9 GAO Shu-gang,SHEN Shu-chang,WANG Wen-bo,CHEN Zhi-qiang,AN Hong*(College of Chem.and Chem.Engineering,Qiqihar Unversity,Qiqihar 161006,China);GC Determination of Phosphatidyl Inositol in Soy Lecithin[J];Physical Testing and Chemical Analysis(Part B:Chemical Analysis);2007-12
10 MENG Qing guo,GAO Er,WANG Ru qin,et al (Applied Pharmacology Laboratory,Weifang Medical College,Weifang 261042,China);The Study on Puerarin Phytosomes Preparation and Its 1H NMR &TLC[J];Journal of Weifang Medical College;2001-01
【Co-references】
Chinese Journal Full-text Database 9 Hits
1 SHI Wen1,GAO Dong-yan2,WANG Jian-xin3,HAN Li-mei1(Department of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 201203,China);Analysis method of gentiopicroside in rat plasma and its application in investigation of preparation technology of phytosome[J];Fudan University Journal of Medical Sciences;2009-03
2 LIANG Na,SHI Kai,WANG Yong-sheng,YU Ying-wei,FENG Li-li,CUI Fu-de(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Preparation and characterization of ferulic acid-phospholipid complex[J];Journal of Shenyang Pharmaceutical University;2008-03
3 SHEN Mei-Pin,SUN Qi,WANG Hong (Institute of Clinical Pharmacology, Shanghai Medical University ,Shanghai 200032);Studies on the intrvenous pharmacokinctics and oral absorbtion of berberine HCI in beagle dogs[J];Chinese Pharmacological Bulletin;1993-01
4 FU Qiu-sheng,YI Shu-zhen(Department of Pharmacy,Naval General Hospital,Chinese PLA,Beijing 100037,China);Preparation and physicochemical properties of kaempferol-3-O-rutinoside phospholipids complex[J];Journal of Pharmaceutical Practice;2009-03
5 XIONG Yang(College of Pharmacy,Zhejiang University of TCM,Hangzhou 310053,China);Apparent partition coefficient of Hawthorn leaf flavonoids in phospholipids complex[J];Chinese Traditional Patent Medicine;2009-07
6 ZENG You-wei1,2,ZHAO Jin-lian1,PENG Yong-hong1(1.College of Life Science,Guangdong Key Laboratory of Biotechnology for Plant Development,South China Normal University,Guangzhou 510631,China;2.Department of Food and Bio-engineering,Guangdong Light Industry Technical College,Guangzhou 510300,China;3.Department of Life Science,Huizhou University,Huizhou 516007,China);Advances in studies on absorption and metabolism of flavonoids[J];Chinese Traditional and Herbal Drugs;2008-03
7 WEN Yue(Dept.of Pharmacy,Daping Hospital,The Third Military Medical University,Chongqing400042,China) HE Yingju,LUO Weiwei(West China College of Pharmacy,Sichuan University,Chengdu610041,China);Determination of Berberine Hydrochloride in Rabbit Plasma by RP-HPLC[J];China Pharmacy;2005-12
8 ZHAO Yi-lei,SONG Yong-xi,LIU Shi-ping(Dept.of Pharmacy,The First Affiliated Hospital of Harbin Medical University,Harbin 150010,China);Preparation and Physicochemical Properties of Phloroglucinol Phospholipids Complex[J];China Pharmacy;2009-19
9 LIU An-chang1,2,ZHAO Li-xia1,ZHAI Guang-xi2,LOU Hong-xiang2,DU Jing-shan1(1.Qilu Hospital of Shandong University,Jinan 250012,China;2.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China);An investigation on Formation mechanisms and preparation of curcumin phospholipid complex[J];China Journal of Chinese Materia Medica;2008-17
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 HE Guo-hou~*,LIU Yong,AI Zhi-bing,ZHANG Xiao-dong,WANG Yun-fu.~*Department of Neurology,Taihe Hospital,Yunyan Medical college,Shiyan 442000,China;Effects of Berberine on Carotid Artery Atherosclerosis in Rabbits[J];Neural Injury and Functional Reconstruction;2006-01
2 Zhou Zuyu, Xu Jianguo, Lan Tingjian.Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China;Protective Effect of Berberine on Isolated Perfused Heart in Heart Failure[J];Journal of West China University of Medical Sciences;2001-03
3 DUAN Hao,ZHANG Hongkao,LIU Jijun,et alThe Affiliated People's Hospital of Yunyang Medical College,Shiyan 442000,China;Effect of Berberine on IL-6 of Carotid Artery after Ballon Injury in Rabbits[J];Journal of Medical Forum;2006-10
4 Hong Ying,Wang Jing,Zhao Haiping,et al.(Beijing University of Traditional Chinese Medicine,Beijing 100102);Influence of berberine on left ventriculer remodeling in rats with hypertrophic cardiomyopathy induced by 2K1C[J];Journal of Beijing University of Traditional Chinese Medicine;2005-06
5 HONG Ying XIE Xin-ran XIE Jun-da ZHAO Hai-ping WANG Jing (Beijing University of Chinese Medicine,Beijing 100102);Influence of berberine on heart structure in rat model with hypertrophic cardiomyopathy induced by pressure-overload[J];Journal of Beijing University of Traditional Chinese Medicine;2006-07
6 ZUO Yan-fang,GUO Yi,JIANG Xin;LI Fang-ming,WANG Qi-zhang. Department of Neurology,the Second Clinical Medical College of Jinan University ,Shenzhen 518020,ChinaCorresponding author:GUO Yi;Effects of berberine on atherosclerosis and plasma levels of lipid in atherosclerotic rabbits[J];Chinese Journal of Cerebrovascular Diseases;2006-05
7 XU Yi, LI Ping, JI Yong (Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China);Effect of Berberine on Cerebral Pial Microcirculation in Cerebral Ischemic Rats[J];LiShiZhen Medicine and Materia Medica Research;2001-12
8 WU Jun Fang, LIU Shao Lin, PAN Xin Xin, LIU Tian Pei (Dept of Pharmacology, Nanjing Medical University, Nanjing 210029);Protective effects of berberine on ischemic injury in cultured rat cortical neurons[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-03
9 DONG De Li, SUN Jian Ping, LUO Da Li, CHEN Qing Wen, WANG Feng, HE Shu Zhuang, YANG Bao Feng (Department of Pharmacology, Harbin Medical University, Harbin 150086, China);Effect of berberine on the cytosolic calcium concentration in the single ventricular cell of guinea pig[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;2000-02
10 Wang Wenya(Wang WY), Chen Kemin(Chen GM)1 and Guan Yongyuan(Guan YY)1 (Department of Pharmacology, Guangzhou Medical College of PLA, Guangzhou 510315; 1Department of Pharmacology, Sun YatSen University of Medical Science, Guangzhou 510089);EFFECT OF BERBERINE HYDROCHLORIDE ON MUSCARINIC RECEPTORS[J];ACTA PHARMACEUTICA SINICA;1999-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved