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《Chinese Journal of New Drugs》 2009-16
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Synthesis of amisulpride

XUE Na1,ZHANG Kai2,YU Wen-guo1,ZHANG Xue-rong1,WANG Gang1(1 Heibei Chemical and Pharmaceutical College,Shijiazhuang 050026,China;2 School of Pharmacy,Hebei Medical University,Shijiazhuang 050017,China)  
Objective:To synthesize amisulpride.Methods:Amisulpride was prepared from 4-amino-5-(ethylthio)-2-methoxy benzoic acid via alkylation,oxidation,and condensation.Results:The total yield of amisulpride with the purity of 99.5% by HPLC was 45.5%,its structure was confirmed by EA,IR,MS,1H-NMR and 13C-NMR.Conclusion:The synthetic route for amisulpride was convenient for industrial manufacture.
【CateGory Index】: R914
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1 LI You, MA Pei-sheng, CHEN Ming-ming, LIANG Yang, WANG Jin-feng (Department of Chemistry Engineering and Technology, Tianjin University, Tianjin 300072, China);Determination and Correlation of the Solubilities with the Ethanol as Solvent and the Main Components of Pure Terephthalic Acid Manufacture Residue as Solute[J];Journal of Chemical Engineering of Chinese Universities;2006-02
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