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Advances in studies on pharmacological effect of parthenolide

ZHOU Min(Department of Biological Engineering,Jiangsu Food Science College,Huaian 223003,China)  
Parthenolide is a sesquiterpene lactone derived from herb feverfew.As a traditional western medicine,it is widely used because of its immunoregulation efficacy and extensive pharmacological effects.It also has antimicrobial and anti-inflammatory effects in vivo and in vitro.The mechanisms of parthenolide are distinct in different cell lines.This article described the recently reported pharmacological effects of parthenolide,such as inhibition of the NF-κB and STAT3 signaling pathway,anti-oxidation and antitumor effects,and reviewed the molecular mechanisms.It will provide references for exploration and utilization of parthenolide.
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