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《Chinese Journal of New Drugs》 2012-16
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Clinical observation of compound Kushen injection combined with cisplatin and cisplatin alone in the treatment of malignant ascites

LIU Xun-yan,XIE Lin-hao,XV Jian-fang,YANG Hon-kai,ZHOU Lan(Department of Internal Oncology,Shantou Central Hospital of Guangdong Province,Shantou 515031,China)  
Objective: To investigate the efficacy and adverse reactions of compound Kushen injection combined with cisplatin(DDP),in comparison with DDP alone,in the treatment of malignant tumors complicated by malignant ascites.Methods: A total of 46 patients with malignant ascites were randomly divided into two groups.They were treated with either intraperitoneal injection of DDP alone or combined with intravenous drip of compound Kushen injection,once a week for four weeks in total.The efficacy and toxicity were evaluated.Results: Combination of DDP with compound Kushen injection was significantly more effective than DDP alone in response rate(60.9% vs 30.4%,P0.05).Patients treated with DDP+compound Kushen injection had significantly less Ⅲ~Ⅳ degree gastrointestinal reactions and liver functional damage than those with DDP alone(P0.05).Conclusion: Compound Kushen injection improves the efficacy of DDP and reduces the toxicities of DDP when it is combined with DDP to treat malignant ascites.
【CateGory Index】: R730.5
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