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Hypoglycemic Effect of Saponin from Tribulus terrestris

Li Mingjuan, Qu Weijing, Wang Yifei , Wan Hong, Tian Cuiping (School of Life Science, East China Normal University, Shanghai 200062; The First People Hospital, Shanghai 200080)  
Objective: To study the hypoglycemic effect of saponin from Tribulus terrestris L. Method: Alloxan was used to establish the diabetic model in mice. Phenformin Hydrochlride Tables was used as the positive control. The level of glucose, triglyceride, cholserol and SOD in serum were determined. Results: The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26.25% and 40.67% in normal mice and diabetic mice in respectively. The level of serum triglyceride could be reduced 23.35%. The saponin could also decrease the content of serum cholsterol. Serum SOD activity of the mice was increased by the saponin. Conclusion: Saponin from Tribulue terrestris could significantly reduce the level of serum glucose.
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