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《Journal of Chinese Medicinal Materials》 2005-11
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Anti-inflammatory Effect and Mechanism of Osthole in Rats

Liu Jianxin,Zhang Wenping,Zhou Li,Wang Xiurong,Lian Qishen(Department of Pharmacology,Gannan Medical College,Ganzhou 341000,)  
Objective: To investigate the anti-inflammatory effect and mechanism of osthole(Ost).Methods: Carrageenan-induced hind paw edema in rats were prepared.The nitric oxide synthase(OOS) activity was measured by NADPH-diaphoras stain assay, nitric oxide(NO) content by Griess diazotization assay,malondialdehyde(MDA) content by Thibabituric acid mehtods.And PG content was assaied by Uv-vis spectrophotometry with 278 nm after 0.5 mol/L KOH methanol reagent dissimilating.Results: The increase in NO~-_2 observed 4h after carrageenan administration was inhibited by Ost from 524.4±58.7/μmol/L~(-1)NO~-_2 for carrageenan alone to 461.5±68.8,353.8±111.0/μmol/L NO~-_2 for,respectively,carrageenan administered in combination with 50 mg/kg or 100 mg/kg Ost.It suggested Ost suppress inflammatory responses on NO levels in a dose-dependent manner(P0.05). In the presence of Ost 100 mg/kg,NOS activities remained at near blank control levels.Meanwhile results showed reduced malondialdehyde production(MDA) in the presence of Ost,which is one of the byproducts of lipid peroxidation.Ost 50,100 mg/kg markedly suppressed the generation of PG in inflamed paws.Conclusion: Ost presents anti-inflammatory activities at the used models.The effects may be associated to a supression of content of PG,NO,MDA and cNOS activity by inhibition of calcium entry and elevating cGMP levels way.
【Fund】: ThisstudywaspartiallyfinancedbytheNaturalScienceFoundationofJiangxiProvince(No.95502)
【CateGory Index】: R285;
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