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《Journal of Chinese Medicinal Materials》 2008-12
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Effects of Huashi Liquid on the Repair to Impaired Gastric Mucosa in Rats with Dampness Retention Syndrome

HAN Zhi-gang1,HUANG Xue-kuan2,LIU Qun-ying2,ZHU Yi2,YANG Jun-qing3(1.Laboratory Animal Center;2.College of TCM;3.Department of Pharmacyology,Chongqing Medical University,Chongqing 400016,China)  
Objective: To investigate the effects of Huashi Liquid on the repair to impaired gastric mucosa in rats with dampness retention syndrome.Methods:Fifty SD rats were randomly divided into normal group,model group,high,middle and low-dose of Huashi Liquid groups,10 rats in each group.Dampness retention syndrome was induced in all rats,except the normal group,by modified enviromental and fatigued method for 6 days.After the model was formed,the normal and model groups were fed with saline(NS) in 2 ml/100 g dose,high,middle and low-dose of Huashi Liquid groups were fed with Huashi Liquid in different dose(0.4 g/100g,0.8 g/100 g,1.6 g/100 g) respectively,one time per day,last for 8 days.Then,the impaired extent of gastric mucosa was observed and the content of superoxide dismutase(SOD),malondialdehyde(MAD) and nitric oxide(NO) in gastric mucosa ware detected.Results:In gastric mucosa of model group,Hyperemia,edema and massive hemorrhagic spots or sludged blood existed,SOD and NO significantly decreased(P0.05),MAD significantly increased(P0.05),compared with the normal group.In gastric mucosa of all the Huashi Liquid,symptoms such as Hyperemia,edema and hemorrhage completely disappeared,SOD and NO significantly increased(P0.05),MDA significantly decreased(P0.05),compared with the model group.Conclusion:Huashi Liquid could repair gastric mucosa impairment of rats with dampness retention,the mechanism may be related to increasing SOD,MAD and decreasing NO content in gastric mucosa.
【Fund】: 重庆市卫生局科研资助项目(2005-B-37)
【CateGory Index】: R285.5
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