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《Journal of Chinese Medicinal Materials》 2012-01
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Study on the Bioactive Constituents of Piper wallichii

ZHAO Guo-wei1,XIA Wen2,CHEN Ping1,HAN En-ji2,XIANG Lan1(1.School of Pharmacy,Shandong University,Jinan 250012,China;2.Qilu Hospital,Shandong University,Jinan 250012,China)  
Objective: To investigate the bioactive constituents in the stem of Piper wallichii.Methods: Compounds were separated by column chromatography of silica gel,ODS-A and Sephadex LH-20.Their structures were elucidated based on spectral analysis.DPPH scavenging activity and AchE inhibitory activity were tested.Results: 10 compounds were isolated and their structures were identified as 3,4-methylenedioxy-benzoic acid(1),vanillic acid(2),benzoic acid(3),N-p-coumaroyltyramine(4),futoenone(5),futoquinol(6),isofutoquinol A(7),4-hydroxy-3,5-dimethoxy-benzoic acid(8),futoamide(9),dihydropiperlonguminine(10).Conclusion: Compounds 1-6 are isolated from P.wallichii for the first time.Vanillic acid(2)and 4-hydroxy-3,5-dimethoxy-benzoic acid(8)show scavenging activity against DPPH radical with ED50 at 224.33μg/mL and 11.44μg/mL,respectively.No compound shows inhibition activity against AchE.
【Fund】: 国家自然科学基金(30271647 81073005);; 山东省优秀中青年科学家科研奖励基金(BS2010YY032)
【CateGory Index】: R284.1
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