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《Journal of Chinese Medicinal Materials》 2015-03
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Intestinal Absorption Characteristics and Mechanism of Polygala tenuifolia Hydrolysate in Rats

HUANG Li-hua;WANG Jian;ZHANG Lu;LUO Shi-lan;CHEN Chang;DU Juan;Chengdu University of Traditional Chinese Medicine;  
Objective: To evaluate the absorption feature and mechanism of tenuifolin( TF) and polygalaxanthone Ⅲ( PT) in different intestinal parts of rats and the impact of MRP2 and P-glycoprotein( P-gp) on it. Methods: In situ unidirectional perfusion was used to detect the concentration of TF and PT through HPLC-DAD with gravimetric method. Furthermore,impact of different parts,cosolvents and inhibitors to TF and PT was also explored with data of Kaand Papp. Results: Tween as cosolvent,Kaand Pappof TF was significantly higher in colon than in other intestinal parts( P 0. 05 or P 0. 01). Whereas,Kaof PT was in sequence of colon,duodenum,jejunum,ileum,but with no significant difference among them( P 0. 05). SDS as cosolvent,Pappof TF was higher in colon than in duodenum( P 0. 05). Kaof TF was significantly higher compared with control when added with VH,an inhibitor of P-gp( P 0. 05). In addition,Pappof PT in different concentration of VH increased( P 0. 05,P 0. 01). Pappof TF significantly increased with IT at the concentration of 0. 02 and 0. 04 mmol / L,an inhibitor of MRP2( P 0. 05,P 0. 01). Meanwhile,Kaof PT,with IT at the concentration of 0. 04 and 0. 08 mmol / L,was significantly higher( P 0. 05,P 0. 01). Conclusion: TF is mainly absorbed in colon,whereas PT is in duodenum. P-gp but not MRP2 influences the intestinal absorption of TF,indicating TF as substrate of P-gp. However,both of P-gp and MRP2 impact the absorption of PT,illustrating PT as substrate of P-gp and MRP2. It also indicates that inhibitors of P-gp and / or MRP2 in combined application may improve the absorption of PT and TF.
【Fund】: 国家自然科学基金资助项目(81173567)
【CateGory Index】: R285.5
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