Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Chinese Medicinal Materials》 2015-03
Add to Favorite Get Latest Update

Intestinal Absorption Characteristics and Mechanism of Polygala tenuifolia Hydrolysate in Rats

HUANG Li-hua;WANG Jian;ZHANG Lu;LUO Shi-lan;CHEN Chang;DU Juan;Chengdu University of Traditional Chinese Medicine;  
Objective: To evaluate the absorption feature and mechanism of tenuifolin( TF) and polygalaxanthone Ⅲ( PT) in different intestinal parts of rats and the impact of MRP2 and P-glycoprotein( P-gp) on it. Methods: In situ unidirectional perfusion was used to detect the concentration of TF and PT through HPLC-DAD with gravimetric method. Furthermore,impact of different parts,cosolvents and inhibitors to TF and PT was also explored with data of Kaand Papp. Results: Tween as cosolvent,Kaand Pappof TF was significantly higher in colon than in other intestinal parts( P 0. 05 or P 0. 01). Whereas,Kaof PT was in sequence of colon,duodenum,jejunum,ileum,but with no significant difference among them( P 0. 05). SDS as cosolvent,Pappof TF was higher in colon than in duodenum( P 0. 05). Kaof TF was significantly higher compared with control when added with VH,an inhibitor of P-gp( P 0. 05). In addition,Pappof PT in different concentration of VH increased( P 0. 05,P 0. 01). Pappof TF significantly increased with IT at the concentration of 0. 02 and 0. 04 mmol / L,an inhibitor of MRP2( P 0. 05,P 0. 01). Meanwhile,Kaof PT,with IT at the concentration of 0. 04 and 0. 08 mmol / L,was significantly higher( P 0. 05,P 0. 01). Conclusion: TF is mainly absorbed in colon,whereas PT is in duodenum. P-gp but not MRP2 influences the intestinal absorption of TF,indicating TF as substrate of P-gp. However,both of P-gp and MRP2 impact the absorption of PT,illustrating PT as substrate of P-gp and MRP2. It also indicates that inhibitors of P-gp and / or MRP2 in combined application may improve the absorption of PT and TF.
【Fund】: 国家自然科学基金资助项目(81173567)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 GU Ling-ling,CHEN Zhi-xiang,LU Wei-gen (National Pharmaceutical Engineering & Research Center,China State Institute of Pharmaceutical Industry,Shanghai 200437,China);Advance on efflux inhibitors inhibiting ABC transporters to improve drug intestinal absorption[J];World Clinical Drugs;2012-03
Chinese Journal Full-text Database 10 Hits
1 ZHANG Jun-ru1,GAO Jia-rong1,WANG Yong-zhong1,DUAN Xian-chun1,XIA Lun-zhu1,2(1.First Affiliated Hospital of Anhui College of TCM;2.R & D Key Laboratory of Chinese Materia Medica of Anhui Province,Hefei Anhui 230031);Study on supercritical CO_2 fluid extraction technology from polygala tenuifolia willd[J];Anhui Medical and Pharmaceutical Journal;2009-07
2 ZHANG Jun-ru1,2,XIA Lun-zhu2,WANG Yong-zhong2,FENG Yi-rong2,GAO Jia-rong2,CHEN Li2(1.Anhui College of Traditional Chinese Medicine,Hefei 230038;2.First Affiliated Hospital of Anhui College of TCM; Grade 3 Laboratory of TCM Preparation;State Administration of TCM,Hefei 230031);Analysis of the extract substrates of polygala tenuifolia Willd.with SFE-CO_2 by GC-MS[J];Anhui Medical and Pharmaceutical Journal;2011-06
3 ZHAO Xiao-xu1,LI Jiang-ying2,CUI Yan-tang1,SUN Zhe1,ZHANG Ya-jun1(1College of Life Sciences,Northwest University,Xi'an 710069,China;2Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710001,China);Assessment of tanshinone Ⅱ_A self-microemulsifying preparation with drug release in vitro and intestinal absorption in situ[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-08
4 TU Peng-Fei △, GUO Hong-Zhu,GUO De-An [Peking University Modern Research Center for Traditional Chinese Medicine (P KUMRCTCM), Beijing 100083,China];Researches on active constituents of natural and traditional medicine and develo pment of new drugs[J];Journal of Beijing Medical University;2002-05
5 ZHANG Jing,XUE Liang;Intestinal absorption of Candesartan cilexetil in rats[J];Academic Journal of Second Military Medical University;2008-08
6 LIN Xiao, XU De-sheng, FENGYi (College of Chinese Materia Medico, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China);Advance in search for intestinal absorption and disposition of drugs[J];The Chinese Journal of Clinical Pharmacology;2004-01
7 HUANG Xin-yan,WANG Yu,ZHANG Xiao-mei,ZHAO Jin-cheng,Zhu Xiao-feng.Institute of Neuroscience,Jiamusi University,Heilongjiang 154007,China;Effects of Polygalaceae Saponins on Neural Stem Cell Differentiation into Neurons[J];Neural Injury and Functional Reconstruction;2011-02
8 GAO Hong-wei1,KUANG Hai-xue2,YAN Xue-ying2 1.The first Attached Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China 2.Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Absorption characteristics of picroside Ⅱ in rat intestine in situ[J];Drugs & Clinic;2011-04
9 Zhang Xiaohua1,Chen Lixue2,Jia Yimin1△(1.Department of Pharmacy,Chongqing Institute of Tumor Research,Chongqing 400030,China;2.Laboratory Research Center,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China);A study of rat in situ intestinal absorption of propranolol hydrochloride through single pass perfusion method[J];Chongqing Medicine;2012-36
10 YANG Benkun,WANG Sujun,ZENG Jie,ZHONG Yunming,ZANG Linquan(School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China);Study of intestinal absorption of cinnamic acid in one-way intestinal perfusion rat model[J];Journal of Guangdong Pharmaceutical University;2013-01
China Proceedings of conference Full-text Database 10 Hits
1 ;Study on in situ Intestinal Absorption of Salvianolic acid B in Rats[A];[C];2008
2 Ying Liu,Zhi Qiang Chen,Xin Zhang,Nian Ping Feng.Ji Hui Zhao,Wu Shan and Tan Rong Department of Pharmaceutics,School of Pharmacy,Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road,Shanghai,201203,P.R.China;An Improved Formulation Screening and Optimization Method Applied to the Development of a Self-microemulsifying Drug Delivery System[A];[C];2009
3 Zhou Shu-xiang,Cheng Gang,Zeng Ling (the First People’s of Changde City,Changde,415003 );Pharmaceutical care for a severe bone trauma patient with secondary infection[A];[C];2012
4 GU Jia-qin,ZHU Jun(Department of pharmacy,Shanghai Chest Hospital,Shanghai 200030,China.);Determination of Specnuezhenide and Naringin in Qiyelin Granules by HPLC[A];[C];2012
5 LI Li- Min;REN Bin;GUO Jie-wen;CHEN Jian-mei;LIU Ruo-xuan;Guangzhou Hospital of Traditional Chinese Medicine;The First Affiliated Hospital of Sun Yat-Sen University;;Analysis of Volatile Compositions of Panax Notoginseng(Burk.) F.H.Chen by HS-SPME- GC-MS[A];[C];2014
6 MENG Shu1 LIN Yu-lian2 ( 1.Yancheng Health Vocational Technical College;Yancheng 224005 2. Yancheng Institute for Drug Control of Jiangsu P rovince,,Yancheng 224002);Content Determination and Quality Evaluation of baicalin in Cholagogic Tablet[A];[C];2012
7 JU Guichun;ZHANG Aiwu;HUANG Wei;HUANG Jie;Chinese Medicine Materials College, Jilin Agricultural University;;Effect of Velvet Antler in Sika Deer on Blood Pressure in Rats[A];[C];2014
8 WEI Xue-ping;MAJin-gang;GUO Fei-yan;WANG Peng-yuan;WANG Xiao-juan;State Key Laboratory of Military Stomatology,Department of Pharmacy,School of Stomatology,Fourth Military Medical University;Institute for Drug and Instrument Control of Lanzhou Military Area Command;;Content Determination of Paraformaldehyde in Mummification Pastes by HPLC with Pre-column Derivatization[A];[C];2014
9 ZhANG Jin-hui;ZHANG Yu;LIU Hai-lin;LI Jie;WANG Zai-hua;Guangdong Key Lab of Ornamental Plant Germplasm Innovation and Utilization,Environmental Horticulture Research Institute,Guangdong Academy of Agricultural Sciences;;Comparative Analysis of Different Organs Polysaccharide Contents of Four Species of Dendrobium[A];[C];2014
10 ZHU Tai-lei;GUO Sheng;TANG Zhi-shu;WANG Ming-geng;LI Guo-long;YANG Jie;QIAN Da-wei;DUAN Jin-ao;Joint Center for Resource and ShaanXi University Of Traditional Chinese Medicine;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization;Shandong Buchang Pharmaceutical Co.Ltd;;Hydrophilic interaction ultra-performance liquid chromatography coupled with tandem mass spectrometry analysis of free amino acids in Notoginseng Radix et Rhizoma[A];[C];2013
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 Wang Ying, Zhou Lingwang, Liu Hong, et al (Keshan Disease Institute of Harbin Universtity of Medical Sciences, harbin 150086);Effect of superposition infection of CVB_4 and CVB_(3m) on T cell subgroups of Kunming mice with deficiency of Se[J];Chinese Journal of Control of Endemic Disenaces;2001-01
2 Zheng Ciuhua Shen Zheng Fushun Hospital of Traditional Chinese Medicine, Department of Psychology, Beijing University;THE EFFECTS OF POLYGALA AND CALAMUS ON SHUTTLE BEHAVIOR AND METABOLIC RATE IN THE BRAIN[J];Journal of Jinzhou Medical Coilege;1991-05
3 Li Guangzhi;Effects of polygala tenuifolia willd on SOD activity of RBC and GSH-Px activity of liver tissue in aging mouse caused by D-galactose[J];HEILONGJIANG MEDICINE AND PHARMACY;2000-01
4 ZHANG Li 1, CHEN Da wei 1, LI Fang jiu 2, SONG Ai hua 3, KUI Gang bo 1 (1 Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 The First Hospital Attached to China Medical University, Shenyang 110001, Chin;Studies on the absorption kinetics of famotidine in rats' intestines[J];Journal of Shenyang Pharmaceutical University;2001-03
5 ZHANG Xiang rong, PAN Wei san (School of Pharmacy , Shenyang Pharmaceutical University, Shenyang 110016, China);Studies on the absorptive kinetics of salvianoic acid A in rats′ small intestines in vivo[J];Journal of Shenyang Pharmaceutical University;2002-01
6 LIU Ying,FENG Nian-ping,XU Jie,WU Shan,ZHANG Xin(School of Pharmacology,Shanghai University of TCM,Shanghai,201203,China);Study on in situ Intestinal Absorption of Bufalin in Rats[J];Lishizhen Medicine and Materia Medica Research;2009-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved