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《Chinese Pediatrics of Integrated Traditional and Western Medicine》 2009-05
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Study on the protective effect of Jiawei Liuwei Dihuang recipe on the hepatic injury of the infancy rats induced by cyclophosphamide

JIANG Rong-yan,ZHU Li-ping,CHEN Shu-ying,et al.Department of Pediatrics,the Affiliated Hospital of Taishan Medical College,Taian 271000,China  
Objective To explore the protective effect of Jiawei Liuwei Dihuang recipe on the hepatic injury of the young rats induced by cyclophosphamide(CP).Methods A total of 32 2-week-old and 3-week-old Wistar rats were divided into three groups,each week-old segment according to the random number table,normal group 8,control group 12 and experimental group 12.Experimental group was fed Jiawei Liuwei Dihuang recipe,2-week-old rats were fed pharyngeal volume 0.6 mL for each,for 3 weeks of age,0.9 mL,twice a day for 14 days.The control group rats were fed normal saline according to weeks,twice a day for 14 days.The experimental group and control group were intraperitoneally injected cyclophosphamide 100 mg/(kg·d) on the 7th day and 8th day;with normal routine feeding,equivalent normal saline was intraperitoneally injected on the 7th day and 8th day for the normal group.Serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were detected on the 15th day.After hematoxylin-eosin staining,the pathological changes in liver tissue were observed by microscope.Results The ALT and AST of the 2-week-old and 3-week-old control rats were significantly higher than the normal group,the difference being of statistical significance(P 0.05);ALT and AST of the experimental group were significantly lower than the control group,the difference being of statistical significance(P0.05).Under light microscope,the cellular swelling of the hepatocyte was moderate to severe in the control group,while liver cell edema was significantly relieved in the experimental group.Conclusion Jiawei Liuwei Dihuang recipe can protect the young rats from the hepatic injury induced by cyclophosphamide.
【CateGory Index】: R285.5
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