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《Preventive Medicine》 2017-06
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A study on teratogenic effects of Chimonanthus salicifolius S. Y. Hu extract on SD rats

ZHENG Yun-yan;YAN jun;ZHU Zhou-jing;CAI De-lei;MENG Zhen;FU Jian-yun;Zhejiang Provincial Center for Disease Control and Prevention;  
Objective To study maternal toxicity,embryotoxicity and teratogenecity of Chimonanthus salicifolius S. Y.Hu in SD rats.Methods A total of 64 successfully mated female SD rats were randomly divided in to 4 groups(16 per group),in which 3 experimental groups were daily treated with 3.75,7.5 and 15.0 g/kg. bw test substance by lavage from7 th to 16 th day during gestation respectively. Body weight and general conditions of the pregnant rats were recorded during the study. On the 20 th day in pregnancy,the rats were anatomized and examined grossly,the fetuses were removed and counted,weight,length,visceral and skeletal changes were then examined. Results There was no significant difference in the conception rate,total weight gain during the pregnancy and the number of living, dead and resorbed fetuses between each dosage groups and the control group(P0.05). The number of the rib, sternum, the fifth sternum punctated and the parietal bone which were ossified defectively all showed no difference among the four groups(P0.05). Conclusion Chimonanthus salicifolius S. Y. Hu extract had no obvious maternal toxicity,embryotoxicity and teratogenecity in SD rats under this experiment condition.
【CateGory Index】: R285.5
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