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Experiment Study of Desertliving Cistanche Polysaccharides on Regulated Haematogenesis in Bone Marrow Depressed Anemia Mice

CHEN Zhi-wei1,ZHU Bi-de1,XU Hui-yu2(1.Chendu University of TCM,Chengdu 610041,Sichuan,China;2.Beijing University of TCM,Beijing 100029,China)  
Objective: to investigate the effect of Desertliving Cistanche Polysaccharides on haematogenesis function in Bone Marrow Depressed Anemia Mice and explore its mechanism for hematopoietic regulation.Methods:built the mold of anemia mice by irradiated CO60 and injected cyclophosphamide,The effect of Desertliving Cistanche polysaccharides on flowcytometry (FCM) respectively and cultured hemopoietic progenitor cell to observe three strain of hemopoietic progenitor cell colony number.Results:It was found that low-dose and high-dose Desertliving Cistanche polysaccharides promoted G0/G1-S phase and S-G2/M phase transition of BMCs, obviously increased the proliferation index and the ratio of G2/M phase cells。Additionally,compared with the control group, the level of CFU-E,BFU-E,CFU-MeG colony number of Desertliving Cistanche polysaccharides group was significant.Conclusion: The data suggest that Desertliving Cistanche Polysaccharides may promote the bone marrow cellcycle transition and the recovery of Hematopoietic function in bone marrow depressed anemia mice, accelerate haematogenesis in rubrum strain and macronucleus strain.
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