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《Chinese Archives of Traditional Chinese Medicine》 2008-01
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Effects of Gypenosides to the Immune Deficit Mouse's Specific Immunological Function

ZHOU Li1,YE Kai-he2,REN Xian-da2(1.Department of Respiratory,Guanzhou TCM Hospital,Guanzhou 510130,Guangdong,China;2.Department of Pharmacology,College of Pharmaceutical,Jinan University,Guangzhou 510632,Guangdong,China)  
Objective:The Gypenosides was used as an immune enhancer to cure the immune deficit mouse and observe specific immunological function by test and delayed hypersensitivity reaction test.The pharmacological funtion of immune enhancer of Gypenosides was evaluated and the dose-effect relationship was discussed.Methods:All of the mice were administrated with CTX and then were divided into six groups:control goup,high dose group,middle group,lowerdose group.Respectively,the hemolysin test and delayed hypersensitivity reaction test was performed in each group and the variation of specific immune function was observed.Results:The test showed that the index of hemolysin test and delayed hypersensitivity reaction test in control group was markedly decreased while the index of hemolysin test high and middle group was increased.The effect of Gypenosides was dose-dependent on the specific immune.Conclusion:The immune deficit model was established successfully by the administration of CTX.Gypenosides was showed markedly to increase the specific immune function and the effectwas dose dependent.The highest recommendation dose was between 200~400mg/kg.
【Fund】: 广州市卫生局科研立项基金资助项目(2003A017)
【CateGory Index】: R285
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