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《Chinese Archives of Traditional Chinese Medicine》 2008-10
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The Experimental Study of SXG Influences on the Expression of E-cadherin CD44V6 and nm23-H1 in Lewis Lung Cancer Metastatic Process

PANG Shu-zhen,GUAN Jian-min,WANG Xu,WU Ai-hua,WANG Zhong-ying,LIU Ying (Heze Medical College,Heze 274030,Shandong,China)  
Objective:To detect SXG influencing on the expression of E-cadherin,CD44V6 and nm23-H1 in Lewis lung cancer metastatic process.Methods:45 mice were randomly divided into three groups:blank control groups,with tumor group and ShanXian granule(SXG) group.Inoculating the mice in the latter two group with tumor cell.The SXG group were given SXG(0.5g/mL) 0.4mL/(one·day),other two groups were given normal saline.Observed the time of the tumor coming into being.The expression of E-cadherin,CD44V6 and nm23-H1 in mice lung and tumor tissue,were measured with the immunohistochemical S-P method.Results:Tumor group compared with SXG group,the former generated tumor faster,the tumor weight were higher and more lung metastasis.There was obviously diffrence between two group(P0.05).Compared with SXG group and blank group,the positive expressive rate of E-cadherin and nm23-H1 was lower,but the positive rate of CD44V6 was higher,there was obviously statistical significance(P0.05,P0.01).Conclusion:The abnormal expression of E-cadherin,CD44V6 and nm23-H1 in the process of Lewis lung cancer form and mecastasis play an important role.SXG can enhance the expression of E-cadherin and nm23-H1,but depress the expression of CD44V6.So SXG has function witch can resist to form and metastasis of malignant tumor.
【Key Words】: ShanXian Granule(SXG) immunohistochemictry E-cadherin CD44V6 nm23-H1:
【Fund】: 荷泽医学专科学校科研项目(H07K01)
【CateGory Index】: R285.5
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