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《Chinese Archives of Traditional Chinese Medicine》 2009-03
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The Changes of ET and NO Contents in Gastric Mucosa Induced by Hemorrhagic-Shock Reperfusione and The Effects of DanShen Extract F.

YAO Chang-bai1,ZHANG Li-hong2,ZHAO Guang-yi2(1.The Affiliated Hospital of Liaoning University of TCM,Shenyang 110032,Liaoning,China;2.The Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning,China)  
Objective:to study the relation between the protective effects of DanShen Extract F(DSEF)on gastric mucosa injury due to Hemorrhagic-Shock reperfusion and the content of endothelin(ET)and nitric oxide(NO)in gastric mucosa.Methods:rats were randomly divided into four groups:group SC(rats undergoing all procedures but hemorrhagic shock);group HE(rats suffered from hemorrhagic shock for 20 min),group NS and DSEF(rats received blood reperfusion after shock for 20min and were killed after 20min).Rats in group DSEF received intravenous infusion of DSEF,and normal saline was infused(0.03mL/min)in the other groups.Result:(1)blood lossing and MAP were similar among group HE,NS,DSEF(P0.05),and there was no marked difference of MAP between before shock and after reperfusion(P0.05).(2)The index of injury in group DSEF was markedly lower than that in group NS(P0.01),and the index in group HE was 0.(3)As compared with those in group SC,the level of NO decreased significantly,but the content of ET increased markedly in group NS(P0.01).In comparsion with those in group NS,the level of NO rose obviously,while the content of ET reduced dramatically in group DSEF(P0.01).Conclusion:the gastric mucosal lesion caused by the reperfusion may be in close contact with the decreasing of NO and the increasing of ET in gastric mucosa and DSEF can inhibit the changes to protect gastric mucosa from reperfusion impairment.
【Fund】: 辽宁省自然科学基金资助项目(2003159)
【CateGory Index】: R285.5
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