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Clinical Observation of Compound Kushen Injection Combined With FOLFOX Regimen in Treatment of Advanced Gastric Cancer

XU Jinxiu,ZHAO Shiye,WANG Airong,WANG Wenjing(The Tumor Hospital of Weihai Municipal Hospital,Weihai 264200,Shandong,China)  
Objective: To observe the effect of Compound Kushen Injection combined with chemotherapy for advanced gastric cancer and tumor markers.Methods: 120 cases of advanced gastric cancer were randomly divided into observation group(60 cases) and control group(60 cases).The control group only received FOLFOX scheme,while the observation group received FOLFOX scheme combined with Compound Kushen Injection.Compound Kushen Injection 15 mL was put into the 0.9% NS 250 mL for intravenous dripping every day,and 10 days was as a cycle.After 2 to 6 cycles of chemotherapy,the effective rate would be evaluated.Results:The objective effective rates of the observation group and the control group RR(CR+PR) were 63.3% and 43.1%,and the disease control rates DCR(CR+PR+SD) were 90% and 74.1%.There was significant difference between the two groups(P0.05).Pain assessment: the pain relief rate in observation group was higher than that of control group(P0.01).There was no significant difference on the level of three tumor markers between two groups' patients.CA72-4 of the control group was decreased significantly after treatment.CA19-9 and CEA although had been decreased but the difference was not statistically significant(P0.05).Three indexes of the observation group were decreased significantly after treatment(P0.05).Conclusion: Compound Kushen Injection combined with chemotherapy can enhance the effect of chemotherapy,relieve pain,and reduce the level of tumor markers in the treatment of advanced gastric cancer.
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