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《Chinese Archives of Traditional Chinese Medicine》 2014-05
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Effect of Haizao Yuhu Decoction with Different Proportions of Sargassum and Radix Glycyrrhizae on Cardiac Function and Renal Function of Goiter Rats

LI Yiwen;ZHONG Gansheng;LIU Haiyan;LIU Yunxiang;WANG Xi;LIU Jia;GAO Yuan;OU Li'na;College of Preclinical Medicine,Beijing University of Chinese Medicine;College of Traditional Chinese Medicine;  
Objective: To investigate the toxic reactions of Haizao Yuhu Decoction with different proportions of Sargassum and Radix Glycyrrhizae in goiter rats through cardiac function and renal function. Methods: We set up seven matched groups according to the principle uniform design( two factors seven level) compared with normal,model,positive groups strictly adhere to SOP. At the end of experiment,we determined blood urea nitrogen( BUN),creatinine( Cr),creatine kinase( CK),lactate dehydrogenase( LDH),serum K+and Na+by automatic analyzer,and weighed the gonad. The data statistic analysis was processed by ANOVA( analysis of variance) in combination with optimized formula soft. Results: The contents of Cr and BUN had no significant difference compared with that of model group. The content of serum K+of group 6 and 7 was increased significantly,and the content of serum Na+was decreased significantly compared with that of model group. The group 1 to 7 could reduce CK activity compared with model group. Matched 2 and 3 groups had pathophysiological change of heart compared with control group. Conclusion: The compatibility of Sargassum and Radix Glycyrrhizae could not show opposite action cardiac and renal functions in this experiment. But it should be analyzed synthetically according to different doses and different processed products in order to expound the conclusions of eighteen incompatible medicaments.
【Fund】: 国家重点基础研究发展计划(973计划)项目(2011CB505300 2011CB505306)
【CateGory Index】: R285.5
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