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《Chinese Archives of Traditional Chinese Medicine》 2017-06
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Study on Analgesic and Anti-Inflammatory Effects and Mechanism of Sophoramine

CHEN Jing;YANG Li;Liaoning University of Traditional Chinese Medicine,Key Laboratory of Provincial Ministry of Construction;  
Objective: To study the Sophoramine( Sophoramine,SA) site of analgesic action and mechanism. Methods: The mice torsion body method,tail flick test and hot plate method were carried on and further observe the effects of CaCl_2 and verapamil on the analgesic effect of Sophoramine. Observe tail flick latency and licking foot latency changes after administration of writhing. The anti-inflammatory effect of Xylene Sophoramine on mice ear swelling model was observed. Results: Sophoramine alkali middle and high dose groups( 30 mg/kg,60 mg/kg) significantly reduced writhing times in mice induced by acetic acid( P 0. 01). Middle and high dose groups' mice tail pain threshold( 30 mg/kg,60mg/kg) at 0. 5 h and 1 h had significant differences compared with the basic pain threshold( P 0. 01) and 2 h pain threshold had significant differences compared with the basic pain threshold( P 0. 05). hot plate experiment,Sophoramine alkali in high dose group( 30mg/kg and 60 mg/kg) for 15 min and 30 min can significantly improve the mice's thermal reaction( P 0. 05,P 0. 01). The pain threshold was the biggest after 45 min administration and the control group's was significantly different( P 0. 01). Sophoramine middle and high dose groups( 30 mg/kg,60 mg/kg) on xylene induced ear edema in mice have obvious inhibitory effect( P 0. 01). The foot licking latency of Sophoramine on mice hot plate reaction could be antagonized by CaCl_2 and enhanced by Vera Pammy. Conclusion: Sophoramine has anti-inflammatory and analgesic effects and its analgesic mechanism may be related with Ca~(2+).
【Fund】: 国家自然科学基金青年科学基金项目(81102901)
【CateGory Index】: R285.5
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【Co-citations】
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1 CHEN Jing;YANG Li;Liaoning University of Traditional Chinese Medicine,Key Laboratory of Provincial Ministry of Construction;;Study on Analgesic and Anti-Inflammatory Effects and Mechanism of Sophoramine[J];中华中医药学刊;2017-06
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