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《China Journal of Basic Medicine In Traditional Chinese Medicine》 2001-09
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Study Antipyretic Effect of Betula Plaatyphylla Suk(BPS) Leaves Extract—Effect on 5-HT、NE、DA in Hypothalamus of Rats

DU Xu, JIANG Zhi jun, LIU Xiao qian, ZHU Yu qi, LIU Lu, ZHANG Lin (Medicament Department, First Clinical College of Harbin Medical University)  
Objective: That study effect of BPS extract on in febrile rats induced by zymonsa and on 5 HT、NE、DA in hypothalamus of rats, provide a scientific evidence for the antipyretic and foblowing effects mecchanism. Method:Amethood with fluorospectrophotometry was esstablished for the determination of 5 HT、NE、DA, The excitation wavelength was 365nm、385nm、325nm and the emission wavelength was 485nm、480nm、375nm. Result:The temperature and content 5 HT、NE、DA in Hypothalamus of rats in model group are all higher than those in control group. The temperature of rats in drug given group fall remarkbally after being given drug 1 hour 5 HT、NE、DA in Hypothalamus fall remarkbally also. Conclusion: Bps extract have antipyretic effect in febrile rats induced by zymosa and its antipyretic effect was associated with its reducing the contents of 5 HT and NE and DA in hypothalamus.
【Fund】: 黑龙江自然科学基金资助项目 (NO 95 2 3)
【CateGory Index】: R285.5
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