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《China Journal of Basic Medicine In Traditional Chinese Medicine》 2003-09
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Antineoplastic Effect of Monkshood Polysaccharide on Mice Transplanted with Tumor Lines of H22 and S180

DONG Lan feng,LIU Jing sheng,MIAO Zhi hui,et al. (College of Pharmacy,Hebei Medical University,Shijiazhuang 050017,China)  
Objective:To investigate the antineoplastic effect of crude Monkshood polysaccharide (CMP) and acid Monkshood polysaccharide (AMP) on mice transplanted with the tumor cell line H22 and S180.Methods:The AMP and CMP were obtained by water extraction and alcohol precipitation.The Kunming mice with H22 and S180 tumor were given peros (PO)or by intraperitoneal injection (IP).The inhibiting rate of tumor growth and life prolongation rate were obscrved,and the lymphocyte transformation capacity,the activity of natural killer(NK) cells,apoptotic rate of tumor tissue,proliferation index (PI) and oncogenes were tested by MTT,LDH method and flow cytometry respectively.Results:CMP and AMP could significantly inhibit the tumor growth.The inhibiting rate of tumor growth in H22(PO) was 45 30% (CMP) and 59 36%(AMP) and in H22{IP} was 49 65%(CMP) and 69 28% (AMP).There were significant differences between the control group and experimental group ( P 0 05 or P 0 01).The result on mice with S180 tumor was alike to that of H22.CMP and AMP could also notably prolong the survival of mice ( P 0 05 or P 0 01),enhanced the spleen weight of rice( P 0 01),increased lymphocyte transformation capacity and the activity of NK cells ( P 0 01 or P 0 05).The results of flow cytometry indicated that CMP and AMP could increase apoptotic rate obviously ( P 0 01),decrease PI and increase expression of p53 and Fas.Conclusion:CMP and AMP have obvious antineoplastic effect,the main mechanism is to enhance the cellular immunologic function,induce apoptosis of tumor tissue and regulate expressions of oncogens.
【Key Words】： Monkshood Polysaccharides Antineoplastic Immunological function Apoptosis
【Fund】： 河北省卫生厅重点科研课题 (No.0 10 5 1)
【CateGory Index】： R285.5
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【References】
Chinese Journal Full-text Database 10 Hits
1 LIU An-jun, CHEN Yan-yan, ZHANG Guo-rong, CHE Wei, MENG Yan-li (College of Food Engineering & Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China);Effects and Mechanism of the Inhibition of H22 Hepatocarcinoma Cell Growth by Cartilage Polysaccharide[J];Modern Food Science and Technology;2007-11
2 JI Chen-feng, ZOU Xiang ,GAO Shi-yong ,JI Yu-bin (Postdoctoral Research of Institute of Materia Medica,Harbin University of Commerce, Harbin 150076, China);Study on anti-tumor effect of three kinds of cactus polysaccharide[J];Journal of Harbin University of Commerce(Sciences Edition);2004-02
3 Cheng Xufeng 1 Zhang Xinfeng2 Liu Qi3 Cai Wenmin3 Liu Xingguo1 The First Affliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450000 Henan Cancer Hospital,Zhengzhou,Henan,China 450008 Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450008;Clinical Observation of Baizhu Fuzi Decoction in the Treatment of Bone Metastases in Breast Cancer[J];China Journal of Chinese Medicine;2012-03
4 ZHANG Xiao-di1,2,LI Yong-jian2(1.Shanghai Traditional Chinese Medical University,Shanghai 200032,China;2.Suzhou Traditional Chinese Medical Hospital,Suzhou 215003,Jiangsu,China);A Review on Treating Caner by Wen Yang Method[J];Journal of Liaoning University of Traditional Chinese Medicine;2009-06
5 ZHOU Shi-qiong;LU Jun-qiu;LI Gui-zhi;ZHOU Yue;WEI Xiao-rui;WANG Xiao-li;Dalu Veterinary Station of Bishan;College of Animal Science and Technology, Guangxi University;;The influence of Gynostemma Polysaccharide on the Spleen and Thymus of Mouse[J];Hubei Agricultural Sciences;2013-17
6 Wu Zeming,Sun Hui,Wang Xijun(Heilongjiang University of Chinese Medicine,Harbin 150040);Research Progress and Prospects:Study of Chemical and Pharmacoligical Properties of Yinchensini-Tang[J];World Science and Technology-Modernization of Traditional Chinese Medicine and Materia Medica;2008-06
7 XIONG Wei1,2,JIAO Yang1,3,LUO Yonghui1,ZHANG Cuixiang1,TAN Deyong2,ZUO Shaoyuan1(1.College of Basic Medicine,Dali University,Dali 671000,China; 2.College of Life Science,Yunnan University,Kunming 650031,China; 3.Institute of Molecular and Clinical Medicine,Kunming Medical University,Kunming 650091,China);Effects of polysaccharide from Lycopus lucidus Turcz. on proliferation of tumor cells in vitro and in vivo[J];Chinese Journal of Bioprocess Engineering;2012-04
8 ZHAO Ya-dong,YANG Jin-kun Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Professor Yang Jinkun's experience in treating pancreatic cancer[J];Shanghai Journal of Traditional Chinese Medicine;2013-06
9 WANG Nan1,LI Lianhui1,LIU Dongmei2 (1.2006 Grade of Chinese Medicine for Seven Years,Shandong University of Traditional Chinese Medicine(Jinan Shandong 250014,China);2.Digestive System Department,Affilited Hospital of Shandong University of Traditional Chinese Medicine(Jinan Shandong 250011,China);Prescription and syndrome identification of Wumei Pills on Curing Antibiotic Associated Diarrhea[J];Journal of Sichuan of Traditional Chinese Medicine;2013-06
10 DONG Lan-feng~1, ZHANG Ying-jun~1, LIU Jing-sheng~2, SONG Shu-xia~1, HOU Jie~1, LU Zhan-jun~ 1* ~1Experiment Animal Department, Hebei Medical University, Shijiazhuang 050017; ~2Lab of Microbiology, Hebei Academy of Medical Science, Shijiazhuang 050021, China;Anti-tumor effect of monkshood polysaccharide with adriamycin long circulating temperature-sensitive liposome and its mechanism[J];Chinese Journal of Cellular and Molecular Immunology;2006-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SUN Zhi guang\+1, ZHAO Wan zhou\+2, LU Yin\+2, TANG Ling fang\+3, ZHANG Zhen ling\+3, ZHANG Shi wei\+2 (1. Department of Digestion, Hospital of TCM of Jiangsu Province, Nanjing 210029; 2. College of Traditional Chinese Herbs, Nanjing University of T;ANTIMUTAGENIC EFFECT OF PROCYANIDINS FROM VITIS VINIFERA SEED IN SALMONELLA TEST[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-03
2 LI Jia-lin,HAI Chun-xu ,LIANG Xin,LIU Rui,WANG Peng (Department of Toxicology,Fourth Military Medical University,Xi‘an710032,Shaanxi,China);Effect of Rhodiola on the Peroxidative Damage Model in Microsomes[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-02
3 HONG Zhen-feng,CHEN Yan-hua,ZHOU Jian-heng,LI Tian-jiao (Department of Traditional and Western Medicines, Fujian College of TCM, Fuzhou,350003,Fujian,China);Experimental Study of Achillea Millefolium L.Extract on Hepatic Injury and Chronic Hepatic Fibrosis[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-01
4 PEI Hai-long et al (Academy of Life Science,Northwest University,Xian,Shaanxi 710069 );Determination on Isopropyl Salicylate Anti-bacterial Activity in vitro[J];Journal of Anhui Agricultural Sciences;2008-34
5 CHEN Xiao-ling et al(Academy of Life Science,Northwest University,Xian,Shaanxi 710069);Determination of Ethyl Salicylate Anti-bacterial Activity in vitro[J];Journal of Anhui Agricultural Sciences;2009-02
6 ZHANG Lin-lin et al(College of Veterinary Medicine,Gansu Agricultural University,Lanzhou,Gansu 730070);Effects of Traditional Chinese Medicine Preparation "Like" on Anti-diarrhea of Mice[J];Journal of Anhui Agricultural Sciences;2009-02
7 CHEN Hong et al (College of Veterinary Medicine,Gansu Agricultural University,Lanzhou,Gansu 730070);Bacteriostatic Test in vitro of Chinese Herbal Medical Compounds against Enteric Pathogenic Bacteria in Livestock and Poultry[J];Journal of Anhui Agricultural Sciences;2009-13
8 XING Yan-mei et al (College of Veterinary Medicine,Gansu Agricultural University,Lanzhou,Gansu 730070);Preparation and Pharmacological Effect of Shuangshen Perfusate[J];Journal of Anhui Agricultural Sciences;2009-13
9 ZHANG Tie et al(College of Chinese Veterinary Medicine,Hebei Agricultural University,Dingzhou,Hebei 073000);Research on the Influence of Cerium Nitrate on the Non-specific Immune Function of Mice[J];Journal of Anhui Agricultural Sciences;2010-03
10 HUANG Xiu-qi (Shangqiu Vocational and Technical College,Shangqiu,Henan 476000);Research on the Defervescence Function of Artemisia apiacea Hance[J];Journal of Anhui Agricultural Sciences;2010-09
China Proceedings of conference Full-text Database 10 Hits
1 NIE Li-rong ZHENG Shu-ming QIU Deng-gao Fish Breeding and Healthy Culture Research Center,Southwest University,Chongqing 402460;Antibacterial Experiment of 12 Chinese herbs active ingredient on 3 bacteria from the Aquatic Products in Vitro[A];[C];2010
2 HAN Lihua (Henan Hospital of TCM,zhengzhou 450008,Henan,China);Study of Lvfukang Capsules on Experimental Arrhythmia Models Induced by Coronary Artery Ligation in Dog[A];[C];2009
3 CHU Mei-na~1,ZHU Yi~2,Yang Jia~1 (1.Chongqing Univercity of Medical Sciences,Chongqing 400016,China.2.Hainan Provincial Institute for Drug Control,Haikou 570216,China);Analgesic and Anti-inflammatory Effects of Total Alkaloids from Stephania hainanensis H.S.Lo et Y.Tsoong and it's Acute Toxicity Study[A];[C];2010
4 Pan Hua-Xin, Wang Pei-Xxun, Zhou Lian, Cao Liu-Ying, Liang Rui-Yan (Immunological Laboratory of Clinical Pharmacology Institute, Guangzhou University of TCM. Guangzhou 510405. China);Comparison of anti-inflammatory and immunosuppress effects of two kind of tablets of tripterygium wilfordii polyglycosidium[A];[C];2006
5 WENG Yan~1,CHEN Wu~1,ZHOU Hong-liang~2,WANG Hai-dan~2 1 Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210036,China; 2 Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China;Study on Multiple Pharmacodynamics index Evaluation for Extraction process of Dog Penis in Wubie Granules[A];[C];2010
6 ;小儿解热栓的药理筛选[A];[C];2006
7 GuoZhong Medical College of Northwest University for Nationalities Lanzhou 730030;Protective effects of YiGanBuGanTang on CCL_4 injured hepatic in rats[A];[C];2006
8 Lai Xiao-ping, Chen Jian-nan, Ye Mu-rong, Hou Shao-zhen, Li Geng- (Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405 );The therapeutic Effect of Isodon lophanthoides var.gerardianus (Benth.) H.Hara on liver-injured animal models[A];[C];2006
9 XING Mao1 ,WANG Qin2 ,YI Mei-tong2 ,AO Li2(1.Dept of Pharmacy; Xinqiao Hospital; Third Military Medical University; Chongqing 400037,China; 2. Dept of Drug Research; Chongqing Hospital of Traditional Chinese Medicine; Chongqing 400020,China );Dose-Effect Relationship of Analgesic and Anti-inflammatory activities of Yugu Capsules[A];[C];2010
10 LI Ke-Hua SHI Dong-Jie LIU Guang-Fen WANG Qing-Chuan (Fujiang Medical University, Fuzhou 350004, China);Effects of Eclipta prostrata on the inflammation induced by the Naja atra venom and the toxicity of venom per se and its cytotoxin[A];[C];2005
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 SHEN Ye-shou,ZHENG Li-jun,WANG Zheng-liang,GU Li-ping(Laboratory of Glycoconjugate and Glycotechnology, Institute of Biochemistry and Microbiology, Anhui University, Hefei 230039,Anhui, China);Experimental Study on Anti-tumor Effects of Intracellular Polysaccharide from Phellinus Linteus[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-04
2 Zhang Yuhui (Chemical Analysis Center, Hefei Milk Company Hefie 231000) Liu Bo (Chemical Analysis Office, Hefei Fresh Milk Production Plant Hefei 231000);The Thermal stability and Chemical Composition of Colostrum[J];JOURNAL OF ANHUI INSTITUTE OF MECHANICAL AND ELECTRICAL ENGINEERING;1998-03
3 Wang Ye1 et al.(1 Bengbu Shengmu Biotechnology Limited Company,Bengbu 233000,China);Effects of Algae Polysaccharides on the Immune Function of Crossing Chickens[J];Anhui Agricultural Science Bulletin;2010-17
4 LI Yong-guan et al (College of Life Science,Northwest A&F University,Yangling,Shaanxi 712100);Study on the Photosynthetic Characteristics of Aconitum carmichaeli Debx.[J];Journal of Anhui Agricultural Sciences;2006-15
5 GENG Xin-cui et al(College of Life Science,Northwest A & F University,Yangling,Shaanxi 712100);Effect of Field Capacity on Radix Aconiti Lateralis Preparata Growth and Protective Enzyme Activities[J];Journal of Anhui Agricultural Sciences;2007-14
6 LIU Ying et al(College of Life Science and Engineering,Southwest University of Science and Technology,Mianyang,Sichuan 621010);Effects of Seed Soaking with Uniconazole Solution on the Morphological and Physiological Index of Wheat Seedlings[J];Journal of Anhui Agricultural Sciences;2007-23
7 LI De-xin et al(Baoding College of Vocational Technology,Baoding,Hebei 071051);Research on Seed Treatments with Different Medicaments and Biological Control of Root Rot of Atractylodes macrocephala[J];Journal of Anhui Agricultural Sciences;2008-15
8 SHUAI Xiao-yan et al(College of Jiujiang,Jiujiang,Jiangxi 332000);The Effects of Nutrient Fluid at Different Iron Levels on the Quality of Culturing Tartary Buckwheat Bud[J];Journal of Anhui Agricultural Sciences;2008-17
9 YAN Ze-sheng et al(College of Forestry and Horticulture,Sichuan Agricultural University,Yaan,Sichuan 625014);Effects of Different Application Method of Boron Fertilizer on Growth and Production of French Bean[J];Journal of Anhui Agricultural Sciences;2008-20
10 LI Yan-ling et al(Zhengzhou College of Animal Husbandry Engineering,Zhengzhou,Henan 450011);Study on Sedation of Dried Ginger[J];Journal of Anhui Agricultural Sciences;2008-32
China Proceedings of conference Full-text Database 2 Hits
1 DONG Xi ZHAO Shi-ping LIU Yan LI Ping Institute of Clinical Medical Sciences,China-Japan Friendship Hospital,Beijing 100029,China Corresponding Author:LI Ping;The protective effect of Liquiritin on injury of the neonate rat cardiomyocyte induced by aconitine[A];[C];2007
2 WANG Bin-hui, FENG Jian, ZHAO Yan-min, WEI Ying-hui, XU Ming, LI Fan-zhu* (College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310053);Simultaneous Pharmacokinetics Study on three aconitine-type alkaloids of Fuzi in Rats[A];[C];2009
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 GAO Jin-sheng,SONG Ai-ying,BI Jun-fang,GAO Lei(Heilongjiang Chinese Traditional Medical University,Haerbin 150040,China);Experimental Study on Anti-tumor Effects of Pingtiaoyin[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-05
2 ZHAO Xiang-sheng et al(College of Life Science and Engineering,Southwest University of Science and Technology,Mianyang,Sichuan 621010);Content Determination of Polysaccharide in Aconitum carmichaili of Jiangyou[J];Journal of Anhui Agricultural Sciences;2009-02
3 WANG Xiao-mei et al(Department of Chemistry and Chemical Engineering,Baoji University of Arts and Sciences,Baoji,Shaanxi 721013);Study on Antioxidative Activity of Polysaccharide in Polygonum cillinerve (Nakai) Ohwi[J];Journal of Anhui Agricultural Sciences;2010-34
4 XIANG Gang et al(College of Agronomy,Sichuan Agricultural University,Chengdu,Sichuan 611130);Optimization of the Extraction Technology of Total Alkaloids from Aconitum gymnandrum Maxim[J];Journal of Anhui Agricultural Sciences;2012-22
5 YANG Li-bin,ZHAO Ning,WANG Jun-fang,et al(Xi'an Medical College,Xi'an,Shaanxi 710021,China);Chemical constituents of the aerial part of Aconitum carmichaeli Debx.[J];Anhui Medical and Pharmaceutical Journal;2011-09
6 LIANG Bei-Bei,LIU Hua-Gang,CAO Jiu-Tao School of Pharmacy,Guangxi Medical University,Nanning,Guangxi,530021,P. R. China;Antitumor Effect of Polysaccharides from Cactus Pear Fruit in S_(180)-bearing Mice[J];Chinese Journal of Cancer;2008-06
7 Zhang Xiaodi,Wu Youting Suzhou Traditional Chinese Medicine Hospital(215009);Study on Apoptosis Induction by Aconite Root in SGC-7901 Gastric Cancer Cell[J];Journal of Zhejiang Chinese Medical University;2011-05
8 YAN Wei,YIN Jian-quan,LI Gui-min,ZHOU Ya-feng,YIN Min-fang (Zhejiang Provincial People’s Hospital,Hangzhou 310024,China);Effect of fermented aconite cake-separated moxibustion in treating dysuria induced by benign prostatic hyperplasia of deficiency of kidney yang[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-12
9 Liu Zeng-Li,Wu Wen-Xiu,Zhang Qiu-Yun (School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China);The Influence of the Prescription of 'Truncation and Inverse Draft' on the ET and TNF-αof Acute-on-chronic Liver Failure Model Rats[J];Chinese Journal of Medicinal Guide;2011-04
10 YANG Fan1,HAO Ai-guo2,XU Heng-gui2,LI Fa-sheng2,LI Ming-yang2 (1.Seven-years Program Clinical Medicine 2003;2.College of Clinical Laboratory,Dalian Medical University,Dalian 116044,China);Detetmination of polysaccharide content of Rhizoma Typhonium Gigantei[J];Journal of Dalian Medical University;2007-05
China Proceedings of conference Full-text Database 1 Hits
1 HUANGhui-lian,LIUke-lan,LIUrong-hua*,SHAOfeng,RENgang,DUANfeng;Studies on HPLC fingerprint of the different producing area of BaiFuPian[A];[C];2010
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Tong Li;Huang Tian-you;Li Ji-Lai;et al (The First Milliatry Medical University of PLA,Guangzhou(510515);Effects of Plant Polysaccharides on Cell Proliferation and Cell Membrane Contents of Sialic Acid,Phospholipid and Cholesterol in S 180 and K 562 Cells[J];CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE;1994-08
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