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《Occupation and Health》 2012-19
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Research on nanoparticle-CdS encapsulation microspheres of supported lecithin using the chitosan and sodium alginate

YU Wen*,DONG Rong-hui,LI Lu,YANG Fu-li *Tanggu Jiefang Street Community Health Center,Binhai New Area,Tianjin,300540,China  
[Objective]To prepare microspheres of supported lecithin using the chitosan and sodium alginate e as the matrix material,with the aid of nanoparticle CdS.Lecithin is not only used as the drug but also surfactant which can replace span-80 or tween-80 in tradition.[Methods]Complex coacervation was the method of preparation of microspheres.The ratio of encapsulation acting as the preparation optimization target,the best technology was screened with orthogonal design.Based on the condition of the best technology,the nanoparticle CdS was added to microspheres.[Results] The optimum condition was chitosan concentration 2.40 mg/ml,stirring speed 800 r/min,reaction temperature 25 ℃,crosslinking agent glutaric dialdehyde 2.0 ml,CdCl2 0.004 mol,Na2S 0.004 mol.[Conclusion]Using liquid paraffin,lecithin,chitosan,alginate,glutaric dialdehyde,microspheres can be prepared without span-80 or tween-80 in tradition.The chitosan lecithin microspheres of nano-CdS has good sustained properties.
【CateGory Index】: R944
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