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《Occupation and Health》 2012-19
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Research on nanoparticle-CdS encapsulation microspheres of supported lecithin using the chitosan and sodium alginate

YU Wen*,DONG Rong-hui,LI Lu,YANG Fu-li *Tanggu Jiefang Street Community Health Center,Binhai New Area,Tianjin,300540,China  
[Objective]To prepare microspheres of supported lecithin using the chitosan and sodium alginate e as the matrix material,with the aid of nanoparticle CdS.Lecithin is not only used as the drug but also surfactant which can replace span-80 or tween-80 in tradition.[Methods]Complex coacervation was the method of preparation of microspheres.The ratio of encapsulation acting as the preparation optimization target,the best technology was screened with orthogonal design.Based on the condition of the best technology,the nanoparticle CdS was added to microspheres.[Results] The optimum condition was chitosan concentration 2.40 mg/ml,stirring speed 800 r/min,reaction temperature 25 ℃,crosslinking agent glutaric dialdehyde 2.0 ml,CdCl2 0.004 mol,Na2S 0.004 mol.[Conclusion]Using liquid paraffin,lecithin,chitosan,alginate,glutaric dialdehyde,microspheres can be prepared without span-80 or tween-80 in tradition.The chitosan lecithin microspheres of nano-CdS has good sustained properties.
【CateGory Index】: R944
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【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 FENG Jia;ZHANG Xiaoyun;SHANG Qing;College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology;;Preparation and Characterization of BSA/PLGA Microspheres with a Novel W/O/O Method and Cell Viability in Vitro[J];河北师范大学学报(自然科学版);2018-02
2 ZHONG Lei;BIAN Fang;ZHAO Chaoyang;ZHANG Hong;Department of Pharmacy, Renmin Hospital of Wuhan University;Department of Pharmacy, Xiangyang NO.1 People's Affiliated to Hubei University of Medicine;;Study on Tetracycline Hydrochloride gastric floating microspheres[J];中国医药导报;2018-07
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