The Effect of Luhuang Granule(芦黄颗粒 )on the Levels of Nitric Oxide and Endothelin-1 in Rabbits with Atherosclerosis
Liu Chunling, et al
Objective:To observe whether intervention with Luhuang Granule(芦黄颗粒 ) may influence the serum level of nitric oxide and the plasma levels of endotheli n- 1 in rabbits with atherosclerosis.Methods:Rabbits with atherosclerosis was i nduced by feeding high- fat diet and arterial intimal injury of ventral aorta w ith balloon.40 New Zealand White rabbits were randomly divided into 5 groups:sha m- operated group(n=8),atherosclerosis model group(n=8),Xuezhikang group (n=8) , high- dose Luhuang Granule group(n=8),low- dose Luhuang Granule group(n=8). Rabbits were fed with different medicines for eight weeks.And the content of nit ric oxide and endothelin- 1 was detected.Results:The content of nitric oxide in high- dose Luhuang Granule group,low- dose Luhuang Granule group and Xuezhika ng(血脂康 ) group increased apparently,and the level of endothelin- 1 decreas ed significantly,as compared with atherosclerosis group.But there was no signifi cant statistical difference to the level of nitric oxide between Luhuang Granule group and Xuezhikang group.Conclusion:Luhuang Granule group is considered to pr otect vascular endothelia dysfunction,which may benefit to prevent the developme nt of aftherosclerosis.
【CateGory Index】： R285