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《Journal of Emergency in Traditional Chinese Medicine》 2006-09
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The Effect of Zhenganxifeng Decoction(镇肝息风汤) on Vascular Smooth Muscle Cells Proliferation and Apoptosis Induced by AngⅡ

Wu Yanxia, Meng Yunhui, Tu Jinwen, et al  
Objective:To investigate the effect of Zhenganxifeng Decoction(ZGXFT,镇肝息风汤 ) on vascular smooth muscle cells proliferation and apoptosis induced by AngⅡ .Methods:Serum containing ZGXFT was produced by the method of serum pharmacology.VSMCs proliferation was observed with the methods of MTT and Brdu immuocytochemistry.VSMCs apoptosis level was examined with the method of flow cytometry.Results:ZGXFT reduced the VSMCS proliferation level which induced by AngⅡ .Compared with the group of VSMCs which was treated with AngⅡ stimulated,VSMCs apoptosis index was increased significantly after ZGXFT treated.Conclusion:ZGXFTcan adjust the apoptosis level of VSMCs induced by AngⅡ .ZGXFT may play a role in cell apoptosis,by which it can inhibit abnormal cell apoptosis which was induce by AngⅡ .
【Fund】: 湖北省武汉市卫生局中西医结合科研课题资助(No.2004-241);; 国家重点基础研究发展计划973项目资助(No.2003CB517104)
【CateGory Index】: R285.5
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