Effects of Integripetal Rhodiola Herb on Spatial Learning and Memory Abilities of AD-like Rats as well as Protein Expression of CAT and GSH-Px in Hippocamps of AD-like Rats
WANG Jian1,LI Li2,CAO Juan1,et al 1Shanxi Medical University(Taiyuan 030001) 2The Second Hospital of Shanxi Medical University(Taiyuan 030000)
Objective:To study the effects of integripetal rhodiola herb(IRH) on spatial learning and memory abilities of AD-like rats as well as protein expression of CAT and GSH-Px in hippocamps of AD-like rats. Methods:AD model was formed. Morris water maze testing system was adopted to observe the changes of rats' learning and memory abilities.Biochemistry testing methods were adopted to observe the protein expression of CAT and GSH-Px in hippocamps of AD-like rats. By means of intragastric administration. Compared with hydergine's effects, IRH was adopted to cure the model rats.Results:The learning and memory abilities of model rats were obviously decreased. All of the test indexes,compared with that of the model group, showed that the abilities of space search, learning and memory in IRH group and hydergine group were remarkably improved. Conclusion:The IRH can improve the model rats' learning and memory abilities as well as the the protein expression of CAT and GSH-Px in hippocamps of model rats,and thus enhance the ability in eliminating excess free radicles.
【CateGory Index】： R285.5