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《Journal of Emergency in Traditional Chinese Medicine》 2009-10
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Effects of Hujin Decoction on Expression of NF-κ B mRNA in the Rats with Acute Lung Injury

YANG Ai-dong,LI Wen-wen,WANG Dong-ying,et al Shanghai University of Traditional Chinese Medicine(Shanghai 201203)  
Objective: To investigate the effect of Hujin Decoction on expression of nuclear factor-κ B(NF-κ B) mRNA in rats with acute lung injury induced by lipopolysaccharide(LPS).Methods:Forty male Wistar rats were randomly divided into 4 groups:normal control group,model group,dexamethasone group and Hujin Decoction group.Each group had 4h and 8h two subgroups.All groups,except normal control group,were administrated with LPS by intravenous injection to induce acute lung injury.The rats in dexamethasone group and Hujin Decoction group were treated by dexamethasone and Hujin Decoction respectively before LPS induced.The animals were killed after injection of LPS for 4h and 8h,and then the expression of NF-κ B mRNA and protein were determined by RT-PCR and immunohistochemistry.The histopathology of the lung injury was observed by light microscope.Results:Compared with model group,the expression of NF-κ B mRNA and protein in the lung tissue were obviously decreased in the two subgroups of Hujin Decoction group.Pathological observation indicates that pulmonary hemorrhage and necrosis were serious in the model group and a better condition in the Hujin Decoction group.Conclusion:Hujin Decoction has protective effects on acute lung injury induced by endotoxin in rats.The drug maybe take effect by means of inhibiting the expression of NF-κ B mRNA and protein in lung tissues.
【Fund】: 上海中医药大学名师传承工程研究项目(No.2005-62);; 上海市教委高校高水平特色发展项目(No.2005-81)
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 1 Hits
1 YAN Long;LAI Yi;The First People Hospital of Xiaoshan District,Hangzhou City,Zhejiang Province;;Effects of Tanreqing Injection on NF-κB of Acute Lung Injury Induced by Endotoxin in Rats Lung Tissue[J];中国中医急症;2015-01
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