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《Journal of Emergency in Traditional Chinese Medicine》 2018-03
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Influence of Buyang Liaoti Decoction Combined with Dermatophagoides Farinae Drops on Serum IL-4,IFN-γ Levels and Immunologic Function of Patients with Allergic Rhinitis of Deficiency-cold Type

WANG Haiying;ZHAO Bobo;MA Dijiang;Yuyao People′s Hospital,Zhejiang;  
Objective: To observe the influence of Buyang Liaoti Decoction combined with dermatophagoides farinae drops on serum IL-4,IFN-γ levels and immunologic function of patients with Allergic Rhinitis of deficiency-cold type. Methods: 102 cases of patients with allergic rhinitis of deficiency-cold type were divided into the observation group and the control group according to random number table method,51 cases in each group.The control group was treated with dermatophagoides farinae drops,and the observation group was treated with Buyang Liaoti Decoction on the basis of the control group. Clinical symptom score and clinical efficacy were observed in the two groups;the levels of IL-4 and IFN-γ and immunologic function were detected in the two groups.Results: After treatment,sneezing,stuffy nose,runny nose,nasal itching score were significantly lower than those before treatment in the two groups(P 0.05),and those in the observation group were significantly lower than those in the control group(P 0.05). Total effective rate of the observation group was 92.16%,significantly higher than that of the control group(74.51%)(P 0.05). After treatment,the levels of IFN-γ,CD3~+,CD4~+and CD4~+/CD8~+in the 2 groups were significantly higher than those before treatment(P 0.05);the levels of IL-4 and CD8~+were significantly lower than those before treatment(P 0.05),and the improvement effect of the indexes in the observation group was better than that in the control group(P 0.05). Conclusion: Buyang Liaoti Decoction combined with dermatophagoides farinae drops can improve serum IL-4 and IFN-γ levels of AR patients of deficiency-cold type,and improve immunologic function and clinical efficacy.
【Fund】: 国家自然科学基金面上项目(81674035);; 中国博士后科学基金第59批面上资助项目(2016M591892);; 江苏省中医药局科技项目(LZ13055)
【CateGory Index】: R765.21
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