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《Acta Academiae Medicinae Sinicae》 1981-S2
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Investigation on Loss of Hair and Nail of Unknown Etiology-Endemic Selenosis

Yang Guangqi, Wang Shuzhen, Zhou Ruihua, Shu Shuang, Man Ronge, Li Shensi, Li Zhenbo, Zhao Xianrong, Liu Biansheng, Shen Changling, Mei Huangyou and Wang Xiangjiu  
Endemic selenosis in animals was believed to have been reported first in 1295 by Marco Polo in Western China,but conclusive evidence had not yet been ob tained in that region. An etiological investigation on this disease in human being was made in Enshi Region,Hubei Province.Results showed that selenium contents in blood and hair of residents in endemic area were far higher than those in nearby nonaffected area, endemic area of Keshan disease and Beijing. Stony coal was proved to be the source of selenium, of which the highest content was 84,000 ppm. The maximal blood selenium level was 7.5 ppm and that of corn and green turnip were 44 and 890 ppm respectively. The average selenium intakes of residents in endemic and nearby nonendemic areas amounted to 5 and 0.75 mg/day respectively. Signs of this disease were loss of hair and nails, skin lesions and nervous symptoms.
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