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Inhibitory Effect of Pingyangmycin on Human Nasopharyngeal Cancer Transplanted in Nude Mice

Zhen Yongsu, Zhang Zhaohe, Wu Shuying and Huang Jing(Institute of Antibiotics, Beijing) Medical Experimental Animal Center , Beijing  
Cancer cells of CNE-2, an established cell line derived from a patient with poorly differentiated nasopharyngeal carcinoma, were transplanted into athymic nude mice.The serially transplanted tumor maintained the appearance of squam-ous cell carcinoma. At a tolerated dosage level, pingyangmycin (bleomycin A5) exhibited a remarkable growth inhibition of the CNE-2 tumor, the inhibition rate being 81%.No histopathological changes were found in the organs of treated animals.
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