Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Sinicae》 1992-05
Add to Favorite Get Latest Update

The Inhibitory Effects of Catechin Derivatives on the Activities of Human Immunodeficiency Virus Reverse Transcriptase and DMA Polymerases

Tao Peizhen, et al (Institute of Medical Biotechnology, Beijing)  
Catechin derivatives including (-)-epicatechin gallate (ECG), (- )-epigall-ocatechin gallate (EGCG), ( - )-epigallocatechin (EGC) and green tea extract (GTE) were found to inhibit the activities of cloned human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT), duck hepatitis B virus replication complexes reverse transcriptase (DHBV RCs RT), herpes simplex virus 1 DNA polymerase (HSV-1 DNAP) and cow thymus DNA polymerase a (CT DNAP a). EGCG and ECG were shown to be, very potent inhibitors of HIV-1 RT. According to the IC50 values for HIV-1 RT, these compounds can be ordered as EGCG 0.0066μmol/LECG 0.084*mol/LGTE 0. 1μg/mlEGC 7.2*mol/L. DHBV RCs RT was the least sensitive to these, compounds. Kinetic study showed that EGCG exerts a mixed inhibition with respect to external template inducer poly (rA).oligo (dT)12-18 and a noncompetitive inhibition with respect to substrate dTTP for HIV-1 RT. Bovine serum albumin significantly reduced the inhibitory effects of catechin analogues and GTE on HIV-1 RT. In tissue culture GTE inhibited the cytopathic effect of coxsackie B3 virus, but did not inhibit the cytopathic effects of HSV-1, HSV-2, influenza A or influenza B viruses.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 WANG Hui (Greening Office of Zhangjiajie District,Jishou University,Zhangjiajie,Hunan 427000);Research on the Extraction of EGCG from Tea Polyphenol[J];Journal of Anhui Agricultural Sciences;2008-21
2 Zhang Yu Zou Guolin Peng Shaojun (College of life sciences, Wuhan University, Wuhan 430072,China);The Research Progress of Epigallocatechin Gallate[J];AMINO ACIDS & BIOTIC RESOURCES;1998-04
3 ZHENG Hong-fa,HUANG Ya-hui(Hunan Tea Research Institute,Changsha 410125,China);Study and Development of High-content EGCG Tea[J];Tea Communication;2007-01
【Citations】
Chinese Journal Full-text Database 4 Hits
1 Cheng Shu-jun,Ho Chi-tang,Lou Huan-zao,Bao Yong-de,Jian Yuan-zhou,Li Min-hsin,Gao Yan-ning,Zhu Ge-feng,Bai Jin-feng,Guo Su-ping,and Li Xiu-qin (Department of Chemical Etiology and Carcinogenesis,Cancer Institute,Chinese Academy of Medical Sciences Beijing,China) (Department of Food Sciences,Rutgers University,New Brunswick,N.J.08903,U.S.A.);A PRELIMINARY STUDY ON THE ANTIMUTAGENICITY OF GREEN TEA ANTIOXIDANTS[J];Acta Biologiae Experimentalis Sinica;1986-04
2 Tao Pei-zhen and Wang Shu-qin (Institute of Antibiotics, Chinese Academy of Medical Sciences, Beijing);PURIFICATION AND CHARACTERIZATION OF HERPES SIMPLEX VIRUS TYPE-I INDUCE DNA POLYMERASE AND ITS SENSITIVITIES TOWARD SOME ANTIBIOTICS[J];;1985-06
3 Tao Pei-zhen, Wang Shu-qin, Zhang Gui-ying,Cai Sheng-yong, Li Huan-lou and Jin Wen-zao Institute of Medicinal Biotechnology, Chinese Academy of Medical sciences, Beijing);NEW ANTIVIRAL ANTIBIOTIC-MUTACTIMYCIN A[J];Chinese Journal of Antibiotics;1990-03
4 Cheng Shujun, et al (Institute of Oncology, Beijing);Inhibitory Effect of Green Tea Extract on promotion and Related Action of TPA[J];Acta Academiae Medicinae Sinicae;1989-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Cheng Shujun, Ho Chitang , Feng Jie, Bai Jinfeng, Guo Suping, Li Xiuqin Cancer Institute, Chinese Academy of Medical Sciences, Beijing Department of Food Sciences, Rutgers University, NY, USA;INHIBITORY EFFECT OF GREEN TEA POLYPHENOLS ON MUTAGENESIS AND CARCINOGENESIS[J];Carcinogenesis,Teratogenesis and Mutagenesis;1989-00
2 Yu Yinnian, Zhang Liyan, Sun Lu , Dai Yifan , Fang Ming , and Chen Xingruo Institute of Basic Medical Sciences, Zhejiang Medical University and Zhejiang Division of Chinese Academy of Medical Sciences, Hongzhou;INDUCTION OF CYTOCHROME P450 ISOZYMES IN FL CELL AND ITS APPLICATION IN SHORT-TERM BIOASSAYS FOR PROVIDING ACTIVATING SYSTEM[J];Carcinogenesis,Teratogenesis and Mutagenesis;1989-00
3 Tong Tong, Cheng Shujun, Li Xiuqin, Bai Jingfeng, and Hara Yukihiko Cancer Institute, CAMS, Beijing 100021, Institute of Medicinal Biotechnology, CAMS; Food Research Laboratories, Mitsui Norin CO., LTD. Japan;INHIBITORY EFFECT OF EPIGALLOCATECHIN GALLATE ON PROMOTION INDUCED BY TPA[J];Carcinogenesis,Teratogenesis and Mutagenesis;1992-01
4 Feng Jinong, Xu Jinkang, Cheng Shujun Institute of Food Safety Control and Inspection, Ministry of Public Health, Beijing 100021 Cancer Institute, Chinese Academy of Medical Sciences;INHIBITORY EFFECT OF EPIGALLOCATECHIN GALLATE ON TRANSFORMATION[J];Carcinogenesis,Teratogenesis and Mutagenesis;1992-01
5 Feng Jie, Cheng Shujun, Li Xiuqin, Guo Suping, Xu Ruixing. and Zhou Yuilan Cancer Insititute, Chinese Academy of Medical Sciences, Beijing 100021, Capital Medical College, Beijing;THEUSE OF SCRAPE- LOADING/ DYE TRANSFER ASSAY FOR DETECTION OF ANTIPROMOTERS[J];Carcinogenesis,Teratogenesis and Mutagenesis;1992-05
6 XIE Hong-mei et al(College of Environmental and Biological Engineering,Chongqing Technology and Business University,Chongqing 400067);Research on the Change Character of Nitrate and Nitrite Content in Tea Water[J];Journal of Anhui Agricultural Sciences;2009-35
7 ZOU Yan-li et al(Department of Chemistry and Life Science,Chuxiong Normal University,Chuxiong,Yunnan 675000);Study on the Extraction and Antioxidant Activities of Pu-Er Crude Tea and Pu-Er Ripe Tea Polyphenol[J];Journal of Anhui Agricultural Sciences;2012-08
8 LIU Shu hong,LI Kun,WANG Mei, et al (Department of Respiratory Diseases, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China);;EFFECTS OF TEA POLYPHENOL ON GROWTH INHIBITION,ANTI-METASTASIS AND INDUCTION OF APOPTOSIS OF LEWIS LUNG CANCER IN MICE[J];Acta Acadimae Qingdao Umvesitatis;2004-02
9 LIU Rong (Department of Chemistry,Baicheng Normal College,Baicheng 137000,China);The Craft Experimental Study on the Extraction,Separation of Tea Polyphenol[J];Journal of Baicheng Normal College;2011-03
10 Bai Xiu-li,Li Xiao-li,Wang Guo-yan (Department chemistry of chang chun teachers college,Changchun 130032 China);Extraction and application of tea polyphenol[J];Journal of Changchun Teachers College;2001-02
China Proceedings of conference Full-text Database 1 Hits
1 ZHANG Ying1,2,ZHONG Yingfu1,2,YUAN Linying1,2,ZHOU Zhengke1,2(1.Tea Research Institute of Chongqing Academy of Agricultural Sciences,Yongchuan 402160,Chongqing,China;2.Chongqing Engineering Research Center for Tea,Yongchuan 402160,Chongqing,China);Preparation and Industrialization of Tea Polyphenols[A];[C];2010
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YangLiansongetal(RiceResearchInstitute,AnhuiAcademyofAgriculturalSciences,Hefei230031);AStudyonAntimicrobialActionandAntisepticEffectofTeaPolyphenolsonSomeCommonPutrefiedMicrobes[J];JOURNAL OF ANHUI AGRICULTURAL SCIENCES;1996-04
2 GUO Jian xia,HUANG Shao Zheng, ZHANG Li seng,ZHANG Li tu (Guangxi Cancey,Institute Guangxi Nanning.530027);EFFECT OF CHINESE GREEN TEA POLYPHENOLS(GTP)ON HUMAN LIVER CANCER CELL IN VITRO[J];CHINESE JOURNAL OF CANCER;1995-06
3 Zhang Yu Zou Guolin Peng Shaojun (College of life sciences, Wuhan University, Wuhan 430072,China);The Research Progress of Epigallocatechin Gallate[J];AMINO ACIDS & BIOTIC RESOURCES;1998-04
4 Lin Qinghua, Yang Qingping, Li Changjian Li Yan (College of life science, Wuhan University,430072) Liu Yanwen (Hubei College of Traditional Chinese Medicine, Wuhan 430061);The Susceptibility of Bacteria Causing Enteritis to the Extract of Origanum vulgare L.[J];AMINO ACIDS & BIOTIC RESOURCES;1999-02
5 Zhang Guoying Li Yanyong Ding Zongyou (Anhui Asricultural College) Wu Yilun He Lina (Anhui Provincial Medicine Research Instiute);In Vitro Experiment on Inhibition of Tea Polyphenol Isolated from Green Tea on Growth of Human Cervical and Lung Cancer Cells[J];Journal of Anhui Agricultural University;1992-03
6 JIANG Chang jun 1,LI Zhuo ming 2,FANG Guo bin 3 (1.Key Laboratory of Tea Biotechnology,Ministry of Agriculture,Anhui Agricultural University,Hefei 230036; 2.General Land Reclamation and Cultivation Co.of Anhui;3.Magushan Mountain Tea and Cocoon Fa;A Preliminary Report on Selecting Improved Tea (Camellia sinensis O.Kuntze) Cultivar Induced by N~+ Ion[J];JOURNAL OF ANHUI AGRICULTURAL UNIVERSITY;2000-01
7 Zhang Guoying and Sun Yuping(Tea Scicnce Department,Anhui AgricuItural UniverSity, Hefei 230036);Toxicty of Tea Polyphenol to Human Embryonic Lung Cells and Monkey Kidney Cells[J];JOURNAL OF ANHUI AGRICULTURAL UNIVERSITY;1994-04
8 Liu Meiqin; Lu Cunfu; Yin Weilun. School of Biological Sciences and Biotechnology, Beijing For. Univ.,Beijing 100083,P.R.China.;Advances in molecular biological study of epigenetics[J];Journal of Beijing Forestry University;2003-03
9 LIU Jia mei, CHEN Dong, WANG Xiao ming (Dept.of Histology and Embryology,School of Basic Medical Sciences,Jilin University, Changchun 130021 China);Effect of lanthanum nitrate on morphology of spleen and IL-2 and IFN-γ levels secreted by splenocytes in rats[J];Journal of Norman Bethune University of Medical Science;2002-02
10 Jin Zhicui;Gao Guang;Chang Jiang;et al(Department of Immunology,Baotou Medical College, Baotou 014010)In this experiment,the 100% decoctum of lycium bararum L was given to the mice(peros),0.2ml/10g(by body weight)a day,for nine days. It was;The Effect of Decoctum of Lycium Bararum Lon the Immune Function of Mice[J];Journal of Baotou Medical College;1997-03
China Proceedings of conference Full-text Database 2 Hits
1 Guo Jichun, Ye Naixing, He Xiaoyan, Zhang Wenjin, Yang Ruxing, Chen Zhihui (Tea Research Institute, Fujian Academy of Agricultural Sciences, 355000);Advance on the Research of Oolong Tea Germplasm Resource[A];[C];2000
2 CHEN Liang, YANG Yajun (Tea Research Institute, Chinese Academy of Agricultural Sciences, 310008);The Application of RAPD in the Investigation of Tea Breeding and Germplasm[A];[C];2000
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Chun_ling, HU Jun_feng, QU Jiang_bin, et al.(School of Public Health, Shandong University, Jinan 250012 , Ch ina);STUDY ON ANTIMUTAGENICITY OF CHINESE HERBAL MEDICINE AND GREEN TEA TO BENZOAPYRENE AND NNK[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-02
2 WANG Chuan-jin et al (School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing,Jiangsu 210094);Study on Decolorization of Extracts of Green Tea[J];Journal of Anhui Agricultural Sciences;2007-04
3 CHENG Liu et al (College of Forestry and Horticulture,Sichuan Agricultural Universality,Yaan,Sichuan 625014);An Overview of Progress in Vitro Culture of in Tea Plants and its Influencing Factors[J];Journal of Anhui Agricultural Sciences;2007-07
4 YANG Xiao-li et al(College of Pharmacy,Dali University,Dali,Yunnan 671000);Caffeine Content Determination of Bowl-shaped Brick Tea in Different Years by HPLC[J];Journal of Anhui Agricultural Sciences;2010-31
5 GUO Yuan-hua,ZOU Guo-lin (College of Life Sciences,Wuhan University,Wuhan 430072);Studies on the Scavenging Effect of Catechin on Superoxide Anion Free Radical and its Self-oxidation[J];Amino Acids & Biotic Resources;2001-02
6 GUO Yuan-hua,ZOU Guo-lin * (College of Life Sciences,Wuhan University,Wuhan 430072);Bacteriostatic Action of Catechin and Interaction of Catechin and Ferric Ion[J];Amino Acids & Biotic Resources;2002-04
7 WU Yan-jun,WANG Xiao-gang,WAN Xiao-chun(Key Laboratory of Tea & Medicinal Plant and Product Safety,Ministry of Agriculture,Anhui Agricultural University,Hefei 230036);Synthesis of methylated EGCG and its stability in artificial simulation gastric juice and artificial simulation intestinal juice[J];Journal of Anhui Agricultural University;2010-04
8 GUAN Chong xin HUI Rui hua HOU Dong yan WANG Lei (Analytical and Testing Research Center,Anshan Teachers College,Anshan Liaoning 114005 ,China);Determination of Caffeine in the Tea[J];Journal of Anshan Teachers College;2001-03
9 HUI Rui-huaHOU Dong-yanLI Tie-chunGUAN Ch ong-xin (Department of chemistry, Anshan Normal University,Anshan Liaon ing 114005,China);Studyies on Chemical Components of Natural Tea[J];Journal of Anshan Teachers College;2002-01
10 Sun Xia,Liang Guoqing,Li Jicheng△ ,etal Zhejiang Provincial H angzhou Medical H igher Professional School (3 1 0 0 1 2 )△Zhejiang University;Studies on Physiological Mechanism of Rhubarb Tan to Weight Loss of Experimental Animal[J];Journal of Zhejiang College of Tcm;2001-04
China Proceedings of conference Full-text Database 5 Hits
1 XIONG Chang-yun, PENG Yuan-ju (Yunnan Vocational College of Tropical Crops, Yunnan Simao 665000, China; Yunnan Agricultural University, Yunnan Kunming 650201, China);The relation between the pigment and quality of biack tea and research advance of its biological activity[A];[C];2006
2 ZHENG Hong-fa1,HUANG Ya-hui1,HUANG Huai-sheng1, CHEN Xiao-yang2 (1. Hunan Tea Research Institute, Changsha,410125,China; 2. Hunan Province three advantage import and export limited company, Changsha 410100,China);Research on The Resources Screening and Suitable Processing Region of Rich EGCG Tea[A];[C];2007
3 Xiaowenjun, Huangtian, Tanjun, Gongzhihua (Tea Key Lab of the Ministry of National Teaching of Hunan Agricultural University, Hunan, ChangSha 410128);Separatian and Purification of EGCG in Catechin by HP-20 Macroporous Resin[A];[C];2008
4 LI Jun, ZHANG Ying-xia, LI Jin-long amd WANG Yao-nan (School of Chemical Bi- ology and Phamaceutical Sciences, Capital University of Medical Sciences, Beijing 100054);Determination of hydrolysable gallic acid in leaves of acer tnmcatum bunge by high performance liquid chromatography[A];[C];2005
5 WANG Xiuping, ZHANG Yinggen, YOU Xiaomei, CHEN Changsong (Tea Research Institute, Fujian Academy of Agricultural Sciences, Fu`an Fujian, 355015, China);Studies on the Daily Infusing Technology Optimization of Taiwan Slightly Fermentation Oolong Tea Based on Promoting the Health Care Function[A];[C];2013
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Cheng Shu-jun,Ho Chi-tang,Lou Huan-zao,Bao Yong-de,Jian Yuan-zhou,Li Min-hsin,Gao Yan-ning,Zhu Ge-feng,Bai Jin-feng,Guo Su-ping,and Li Xiu-qin (Department of Chemical Etiology and Carcinogenesis,Cancer Institute,Chinese Academy of Medical Sciences Beijing,China) (Department of Food Sciences,Rutgers University,New Brunswick,N.J.08903,U.S.A.);A PRELIMINARY STUDY ON THE ANTIMUTAGENICITY OF GREEN TEA ANTIOXIDANTS[J];Acta Biologiae Experimentalis Sinica;1986-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved