Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Sinicae》 1999-04
Add to Favorite Get Latest Update

Influence of Radiation on the Blood Brain Barrier and Optimum Time of Chemotherapy

Qin Dexing # Zheng Rong Ma Jinlan Xiao Jianping Tang Zhiqiang# Corresponding author (Department of Radiotherapy,Cancer Hospital,CAMS and PUMC,Beijing 100021)  
Objective A pilot study of the destructive effects of radiation on the blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCSFB) were carried out on 29 patients.Methods (1) First BBB with localized and limited brain tumors was examined by 99m Tc GH imaging count/pixel,data was obtained from the unirradiated, irradiated, and tumor areas of before and after radiotherapy of 20~40 Gy respectively. (2) The BCSFB was studied quantitatively by observing the effect of methotrexate (MTX) permeation into the CSF before, during, and after brain irradiated after i.v.injection of MTX.Results (1) the BBB in the unirradiated area outside the radiation portal was not changed, (2) the degree of destructive effect on the BBB in the irradiated normal area and on the BCSFB were directly proportional to radiation doses.Conclusions When the permeation of BBB and BCSFB irradiated, was enhanced the degree of destructive effect were enhanced proportionally with irradiation doses. It was that the BBB irradiated can be recovered at least partially after irradiation of 3 weeks proved. After a dose of 20 Gy irradiation, the BCSFB would gradually open. As compared with the pre radiation data, the permeability of MTX increased by 1 05~1 3 times. So, it was advisable to give chemotherapy after 20 Gy irradiation.
【CateGory Index】: R815
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 4 Hits
1 Yong Wu,Guo-Long Liu Department of Oncology,First People's Hospital of Guangzhou,Guangzhou 510180,P. R. China;Radiotherapy-induced Blood-brain Barrier Disruption and its Implications for Chemotherapy[J];Chinese Journal of Neuro-Oncology;2007-01
2 JIANG Jun1,WEI Wei-hong1,FENG Yan-lin2,ZHOU Yu-chao1,LUO Wei-jun1,YUAN Jian-wei2,ZHANG Guo-yi1,L Zhi-qian1 1Department of Radiotherapy,2Department of Nuclear Medicine,Foshan First People's Hospital,Foshan 528000,China;Application of ~(99)mTc-DTPA in evaluation of blood-brain barrier permeability in patients receiving whole brain irradiation[J];Journal of Southern Medical University;2010-02
3 GUO Zhi-tong,ZHU Cheng,ZHANG Yi,et al.(Department of Neurosurgery,Bengbu Third People's Hospital,Anhui 233000,China);Microsurgical treatment of medulloblasoma[J];Journal of Huaihai Medicine;2005-02
4 ZHAO Fan 1, ZHAO Yong-xin 2, XIAO Yong-jun 2, SUN Yan-liang 2 1.Department of Oncology,Wuxi Second Affiliated Hospital of Nanjing Medical University,Wuxi 214002, P.R.China 2.Huaihua Affiliated Hospital of Nanhua University, Huaihua 418000, P.R.China;Study of pharmacokinetics in cerebrospinal fluid during high dose methotrexate chemotherapy[J];Journal of Qilu Oncology;2004-12
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CHEN Li-kun, LIU Guo-zhen, XU Guang-chuan* Department of Medical Oncology, Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, P.R. China;Brain Irradiation Enhances Permeability of cis-Diamminedichloroplatinum into Blood-Brain Barrier[J];Chinese Journal of Cancer;2001-03
2 FAN Yun, HUANG Zhi yu, ZHANG Yi ping, SUN LinDepartment of Chemotherapy,Zhejiang Cancer Hospital,Hangzhou 310022,P.R.China;Teniposide and Cisplatin Compared with Etoposide and Cisplatin for Treatment of Small Cell Lung Cancer[J];Chinese Journal of Cancer;2002-12
3 Gang Li1, Bao-shi Chen2, Cheng Yang3, Jian-kun Xu4, Zheng-tang Chen5, Wen-liang Li6, Min-hui Xu7, An-min Li8, Bo Han9, Ping Yang10, De-xiong Chen11, Zhi-gang Wang12, Qin-bi Dai13, Jian-wen Gu14, Wen-yuan Tang15, Zhong-ping Chen1 1. State Key Laboratory for Cancer Research in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P.R.China; 2. Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, P.R.China; 3. the ninth People's hospital of Chengdu, Chengdu 610083, P.R.China; 4. Xuanwu Hospital of Capital Medical University, Beijing 100053, P.R.China; 5. Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R.China; 6. Tianjin Tumor Hospital, Tianjin 300060, P. R. China; 7. Daping Hospital. Third Mililary Medical University, Chongqing 430042, P.R.China; 8. No. 304 Hospital of Chinese PLA, Beijing 100030, P.R.China; 9. the First Hospital of Harbin Medical University, Harbin 150001, P.R.China; 10.Naval General Hospital of Chinese PLA. Beijing 100037. P.R.China; 11.Chang Jiang shipping General hospital, Wuhan 430010, P.R.China; 12. No. 161 Hospital of Chinese PLA, Wuhan 430010, P.R.China; 13. Chongqing Tumor Hospital, Chongqing 430042, P.R.China; 14. General Hospital of Chengdu Military Command, Chengdu , Sichuan 610083, P.R.China; 15.The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R.China;;Teniposide and Nimustine Regimen for Brain Metastases from Neoplasm of Lung[J];Chinese Journal of Neuro-Oncology;2008-02
4 KUANG Fang, WANG Bai Ren, JU Gong Institute of Neuroscience of Chinese PLA, Fourth Military Medical University, Xi'an 710033, China;Effect of intravenous injection of lipoplysaccharide and small dose of adrenaline on the opening of blood brain barrier[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-01
5 William Chi-shing CHO Department of Clinical Oncology,Queen Elizabeth Hospital,Hong Kong,China;Integrated therapy and research progress in molecular therapy for intracranial tumor[J];Journal of Southern Medical University;2007-07
6 LIU Junling, LIU Guozhen, XU Guangchuan, CHEN Likun, LIANG Ying. Department of Medical Oncology, Tumor Hospital of Sun Yat sen University, Guang zhou, Guangdong 510060, P.R.China;Concomitant whole brain radiotherapy and FUDR+VM-26+DDP chemotherapy in brain metastasis of non-small cell lung cancer: a report of short term efficacy[J];Chinese Journal of Lung Cancer;2003-05
7 Cheng Peng1,Song Liang2,Zou Hong3(1.Department of Oncology,the First Affiliated Hospital of Nanyang Medical College;2.Department of Applied Mathematics,Nanyang Institute of Technology;3.Department of Radiology,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,China);Concomitant Whole Brain Radiotherapy and VM26+DDP+PTX Chemotherapy in Brain Metastasis of Lung Cancer[J];Journal of Basic and Clinical Oncology;2008-04
8 LIU Yicheng,JIA Qing,XIA Liming,et al. Department of radiology,The first hospital of Wuhan, Wuhan ,430030, china.;MR diagnosis on cerebellum medulloblastoma[J];Chinese Imaging Journal of Integrated Traditional and Western Medicine;2004-01
9 ZHONG Ping, XU Jian, GAO Xiang Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040; Department of Neurosurgery, Shanghai Medical College, Fudan University, Shanghai 200032, China;Diagnosis and Treatment of Glioma (Report of 296 Cases)[J];Chinese Journal of Clinical Neurosciences;2007-01
10 Liu Bin,Li Ling,Jin Bilian.Department of Neurosurgery,Tongji Hospital,Tongji Medical University,Wuhan 430030;Opening of blood-brain barrier in rats following interstitial laser thermotherapy[J];CHINESE JOURNAL OF STEREOTACTIC AND FUNCTIONAL NEUROSURGERY;2000-03
【Secondary References】
Chinese Journal Full-text Database 8 Hits
1 Yong Wu,Guo-Long Liu Department of Oncology,First People's Hospital of Guangzhou,Guangzhou 510180,P. R. China;Radiotherapy-induced Blood-brain Barrier Disruption and its Implications for Chemotherapy[J];Chinese Journal of Neuro-Oncology;2007-01
2 WANG Hao, QI Song-tao, GUO Zhi-wang, WANG Ke-wan, LIU Xiao-jun, ZHANG Guo-zhong Department of Neurosurgery, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China;Histomorphology of angiogenesis patterns in different areas of human astrocytomas[J];Journal of Southern Medical University;2009-02
3 CHEN Liang, CHEN Xuemin (Department of Pharmacy, Doping hospital of'Third Military Medical University, ChongQing 400042);Research development of targeted drug delivery system in China[J];Journal of Pediatric Pharmacy;2003-01
4 ZHENG Shu-Zhan, JIAN Ya-Jun, BAI Yin-Juan, XIE Zhan-Feng, CHANG Jian-Hua* (Department of Chemistry, Northwest University, Xi′an 710069, China);Synthesis, Relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) Complexes with Dihydropyridine Derivatives of Diethylenetriaminepentaacetic Acid[J];Chemical Research In Chinese Universities;2004-09
5 GAO Chen1,2,GAO Min2,SHI Wei-zhong2,ZHAO Zhi-gang2,SUN Hao2,ZHAO Xiu-li1(1.Department of Pharmacology,Beijing Tongren Hospital,Capital Medical University,Beijing 100710,China;Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China);Experimental study on the effect of borneol for methotrexate penetrating across blood brain barrier[J];The Chinese Journal of Clinical Pharmacology;2009-02
6 Li Chengcheng~(1,2),Yang Yongjian~(2,3),Tian Jinghui~(1,3),Yang Kehu~(1,3) 1.Centre of Evidence-based Medicine of Lanzhou University,Lanzhou 730000,China; 2.School of Pharmacology of Lanzhou University;3.School of Basic Medical Science of Lanzhou University;Systematic Review of Adjuvant Chemotherapy for Adults with Malignant Glioma[J];Chinese Journal of Pharmacoepidemiology;2009-04
7 WANG Dong-xing, GAO Yong-liang, YUN Liu-hong(Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing 100850, China);Advances on brain-targeted nasal delivery system[J];Chinese New Drugs Journal;2005-02
8 JIANG Hai-yang1,YANG Yang1,FU Jian-ping1,XUE Yi-xue2(1.Clinical Medicine of Seven-year,China Medical University,Shenyang 10001,China; 2.Department of Neurobiology,China Medical University,Shenyang 110001,China);Related Method of Selective Opening Blood Brain Barrier[J];Medical Recapitulate;2010-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved