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Effect of Propofol and Etomidate for Anesthesia Induction on Plasma Total Cortisol Concentration

Zhang Yajun Luo Ailun An Gang Huang Yuguang(Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China)  
To investigate the effect of propofol and etomidate for anesthesia induction on adrenocortical function. Methods The plasma total cortisol concentration was determined in 20 patients who were treated with propofol or etomidate. Results After propofol induction,the plasma total cortisol level decreased from (308.7±27.4)nmol/L to(267.7±31.2)nmol/L at postmedication 2 hours,increased to (400.2±26.9)nmol/L at postmedication 5 hours and restored to premedication level at postmedication 24 hours[(306.4±35.4)nmol/L].After etomidate induction,the plasma total cortisol level decreased from(309.1±36.6)nmol/L to (115.9±29.7)nmol/L at postmedication 2 hours, maintained (171.1±34.7)nmol/L at postmedication 5 hours and restored to premedication level at postmedication 24 hours[(311.8±46.2)nmol/L]. Conclusions Propofol induction has little effect on adrenocortical function whereas etomidate induction inhibits adrenocortical function.
【CateGory Index】: R971
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