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《Clinical Journal of Chinese Medicine》 2015-20
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Effects of acanthopanax saponins on learning and memory capability and LTP in the hippocampal CA1 of aging rats

Objective: To observe the effects of ASS on learning and memory capability and LTP in hippocampal CA1 area of the aging rats induced by D-galactose. Methods: 27 SD rats were randomized into 3 groups. The models of aging rats were given injecting D-galactose(120mg·kg-1·d-1). The rats in the ASS group were treated with ASS solution(5mg·kg-1·d-1, IP); the rats in the control group were treated with the same dose of saline. After 42 days, the learning and memory capability were detected in Morris water maze; electrophysiological method was used to observe the LTP in hippocampal CA1 area. Results: The Morris water maze test showed that ASS significantly improved learning and memory performance in aging rats. In the electrophysiological experiments, PS amplitude significantly decreased in model group versus control, and ASS treatment restored PS amplitude. Conclusion: ASS can improve learning and memory ability and LTP in the hippocampal CA1 of aging rats, and this effect could be attributed to improvement of synaptic dysfunction.
【CateGory Index】: R285.5
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