Effects of Extract from Dipsacus Asperoides on Anti-oxidation and Learning-memory Abilities in D-Galactose-induced Mice
He Xuexin, Qiu Jun (Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,P.R.China)
Objective: To observe the effect of extract from Dipsacus asperoides (DA) on the learning-memory ability in D-galactose-induced mice and its effect of anti-oxidation. Method: Mice were trained by Y-mazea and their learning-memory abilities was detected before injection of D-galactose. Then the mice were divided into seven groups on the basis of conditions, of which the same level of learning-memory abilities each group. The mice were orally administrated with different doses of DA′s extracts for 49 d. The learning-memory abilities,the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) from brains and peripheral blood were determined. Result: Compared with model group, the learning-memory abilities of the mice orally administrated with DA’s n-bectanol extract ((7.5) g·kg~(-1),10 g·kg~(-1)) and water extract (20 g·kg~(-1)) was better; the SOD activity of brains with n-butanol extracts (10 g·kg~(-1))was higher, and the MDA concentrations in peripheral blood of DA’s extract were lower. Conclusion: DA’s n-butanol extract and water extract can improve the learning-memory abilities of D-galactose induced mice, and show the action of anti-oxidation.