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《China Pharmacist》 2005-05
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Determination of Telmisartan in Plasma by HPLC with Fluorescent

Ye Zhiqing( Department of Pharmacology, Medical College of Wuhan Universsity, Wuhan 430071 ,P. R. China) ;Liu Dong( Department of Pharmacy, Tongji Hospital) ;Zhou Jinhe( Department of Pharmacy, the Sixth Hospital of Wuhan city)  
Objective: To establish a HPLC for the determination of concentration of telmisartan in human plasma. Method: The samples were chromatographed on a symmetry-C18 reversed-phase column and monitered by fluorescene-detection at the EX300 and EM385 nm. The mobile phase consisted of 0. 05 mol·L-1 of potassium dihydrogen phosphate-acetonitrile(55:45,pH=3. 65) with a flow rate of 1. 0 ml·min-1. Result: The calibration curve was linear within a range of 1.0-500 μg·L-1 ( r = 0. 999 8). The RSD of in-tra-day and inter-day were less than 10% . The absolute recovery of three kinds of concentration were 96. 6% ,98. 46% , and 104. 43% , respectively. The limit of quantificaiton was 1 μg·L-1. Conclusion: This method had a good selectivity,sensitivity, and reproducibity. This method was shown to be suitable for pharmacokinetic study on telmisartan in human, and monitoring the plasma level of drug in clinic.
【CateGory Index】: R96
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1 QI Yang-hai1, ZHANG Peng2, LIAN Jiang-ping2, LI Xiao-chuan2, DING Yuan, GU Yi3 (1. Xi'an Qinghua Hospital, Xi'an 710025,China; 2.Department of Pharmacy,The People's Hospital of Shannxi Province, Xi'an 710068,China;3. Department of pharmacy ,Stomatological College, the Fourth Military Medical University, Xi'an 710032,China);Determination of telmisartan in human plasma by HPLC with fluorimetric detection and study on its pharmacokinetics[J];西北药学杂志;2007-04
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6 Ye Zhiqing( Department of Pharmacology, Medical College of Wuhan Universsity, Wuhan 430071 ,P. R. China) ;Liu Dong( Department of Pharmacy, Tongji Hospital) ;Zhou Jinhe( Department of Pharmacy, the Sixth Hospital of Wuhan city);Determination of Telmisartan in Plasma by HPLC with Fluorescent[J];中国药师;2005-05
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