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《China Pharmacist》 2005-05
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Determination of Telmisartan in Plasma by HPLC with Fluorescent

Ye Zhiqing( Department of Pharmacology, Medical College of Wuhan Universsity, Wuhan 430071 ,P. R. China) ;Liu Dong( Department of Pharmacy, Tongji Hospital) ;Zhou Jinhe( Department of Pharmacy, the Sixth Hospital of Wuhan city)  
Objective: To establish a HPLC for the determination of concentration of telmisartan in human plasma. Method: The samples were chromatographed on a symmetry-C18 reversed-phase column and monitered by fluorescene-detection at the EX300 and EM385 nm. The mobile phase consisted of 0. 05 mol·L-1 of potassium dihydrogen phosphate-acetonitrile(55:45,pH=3. 65) with a flow rate of 1. 0 ml·min-1. Result: The calibration curve was linear within a range of 1.0-500 μg·L-1 ( r = 0. 999 8). The RSD of in-tra-day and inter-day were less than 10% . The absolute recovery of three kinds of concentration were 96. 6% ,98. 46% , and 104. 43% , respectively. The limit of quantificaiton was 1 μg·L-1. Conclusion: This method had a good selectivity,sensitivity, and reproducibity. This method was shown to be suitable for pharmacokinetic study on telmisartan in human, and monitoring the plasma level of drug in clinic.
【CateGory Index】: R96
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Chinese Journal Full-text Database 3 Hits
1 ZHU Rui1,LI En-guang2,ZHANG Peng1,ZHAO Huai-qing1(1.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China;2.School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China);Relative bioavailability of telmisartan tablets[J];沈阳药科大学学报;2011-12
2 WANG Yongchun1,FEI Pingxia1,XI Yunfei1,TIAN Yuning2(1.Dept.of Pharmacy,The Affiliated Hospital of Ningxia Medical University,Ningxia Yinchuan 750004,China;2.Dept.of Pharmacy,The Ankang Hospital of Ningxia Public Security Department,Ningxia Yinchuan 750004,China);Determination of telmisartan in human plasma by RP-HPLC[J];西北药学杂志;2011-01
3 Tao Daren,Sun Li,Shen Jinfang(Clinical Pharmacology Dept.,Renji Hospital affiliated to Shanghai Second Medical University,Shanghai 200001, P. R. China);Determination the Content of Telmisartan in Human Plasma by HPLC[J];中国药师;2006-03
Chinese Journal Full-text Database 10 Hits
1 QI Yang-hai1, ZHANG Peng2, LIAN Jiang-ping2, LI Xiao-chuan2, DING Yuan, GU Yi3 (1. Xi'an Qinghua Hospital, Xi'an 710025,China; 2.Department of Pharmacy,The People's Hospital of Shannxi Province, Xi'an 710068,China;3. Department of pharmacy ,Stomatological College, the Fourth Military Medical University, Xi'an 710032,China);Determination of telmisartan in human plasma by HPLC with fluorimetric detection and study on its pharmacokinetics[J];西北药学杂志;2007-04
2 XU Hong-rong DAI Pei-fang WANG Hong CHU Nan-nan (Clinical Trail Research Center on New Drugs,Zhongshan Hospital,Fudan University,Shanghai 200032,China);Pharmacokinetics of compound telmisartan tablets in Chinese healthy volunteers[J];中国临床药学杂志;2007-03
3 HUANG Peng~1,ZHANG Hong~2,XU Wen-Wei~2,LI Yan-Yan~2,XIONG Yu-Qing~2~1Department of Epidemiology,School of Public Health~2Institute of Clinical Pharmacology,Jiangxi Medical College,Nanchang 330006,China;Pharmacokinetics and bioequivalence of telmisartan in Chinese healthy volunteers[J];第四军医大学学报;2006-18
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6 Ye Zhiqing( Department of Pharmacology, Medical College of Wuhan Universsity, Wuhan 430071 ,P. R. China) ;Liu Dong( Department of Pharmacy, Tongji Hospital) ;Zhou Jinhe( Department of Pharmacy, the Sixth Hospital of Wuhan city);Determination of Telmisartan in Plasma by HPLC with Fluorescent[J];中国药师;2005-05
7 GAO Ling~1, LIU Qian~1, YU Zhi-guo~1, ZHAO Huai-qing~1,BI Kai-shun~1, GENG Yu-xian~2, SHUAI Xiao-tian~2 (1 Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Beijing Winsunny Pharmaceutical Co., Ltd., Beijing 101113, China);The relative bioavailability of telmisartan tablets[J];中国新药杂志;2005-04
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9 WU Jie,FENG Fang,JIANG Juan-Juan,TIAN Yong (Department of Pharmaceutical Analysis,China Pharmaceutical University,Nanjing 210009,China);Determination of Telmisartan in Human Plasma by HPLC-MS and Study of Its Pharmacokinetics[J];中国药科大学学报;2004-06
10 JIA Lin-Jing, WEN Qiang, QIAO Hai-Ling, ZHANG Qi-Tang, ZHANG Li-Rong, GUO Yu-Zhong, GAO Na, TIAN XinDepartment of Clinical Pharmacology, Medical College , Zhengzhou University, Zhengzhou 450052 , Henan, China;Pharmacokinetics of telmisartan tablets in healthy volunteers by HPLC[J];中国临床药理学与治疗学;2004-11
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 Li Zhonghong;Zhang Mei;Fan Xialei;Zhou Wei;Ding Yimei;Zhou Yinqi;Lü Wenli;Jiangsu Institute for Food and Drug Control;Jiangsu Provincial Institute of Materia Medica;The University of Tennessee Health Science Center;;Study on the Formulation and Process of Telmisartan's Oral Solid Preparations by Thermal Analysis Methods[J];中国药品标准;2014-03
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