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《China Pharmacist》 2014-06
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Efficacy Observation of Diosmin Tablets in the Treatment of Lumbar Intervertebral Disc Protrusion in Acute Stage

Cao Jin;Hu Fenggen;Wang Dayong;Zhang Xuchen;Wang Ding;Department of Orthopedics,Affiliated Yuhang Hospital to Hangzhou Normal College Medical College;  
Objective: To observe the therapeutic efficacy of diosmin tablets in the treatment of lumbar intervertebral disc protrusion in acute stage. Methods: Totally 210 cases of patients with lumbar intervertebral disc protrusion were randomly divided into the treatment group( 115 cases) and the control group( 95 cases). The treatment group stayed in bed absolutely for two weeks and received diosmin tablets orally with 2 tablets each time( 0. 45 g per tablet) and three times a day for 10 days( one treatment course). The control group stayed in bed absolutely for two weeks and received rapid intravenous dripping of mannitol combined with dexamethasone for 3days. The clinical efficacy,VAS scores and adverse drug reactions were observed and compared between the two groups. Results: The total effective rate of the treatment group was 86. 08%,and that of the control group was 89. 47%,suggesting the therapeutic efficacy of the two groups was similar. The score of VAS of the two groups were decreased significantly after the treatment( P 0. 05). After 3days treatment,the score of VAS in the treatment group was higher than in the control group( P 0. 05),however,there was no statistical significance( P 0. 05) between the two groups after 10 days treatment. Conclusion: Diosmin tablets show obvious effect on lumbar intervertebral disc protrusion in acute stage.
【CateGory Index】: R681.53
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【References】
Chinese Journal Full-text Database 1 Hits
1 LI Yu-shan;Shanxi Huifeng Pharmaceutical Co.,Ltd.;;Research Progress of Pharmacological Action and Clinical Application of Diosmin[J];海峡药学;2015-12
【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Gaojian, CHEN Chengdong. Department of General Medicine, Sanhe Health Care Unit, Deqing 313200, China;Expression and significance of IL-20, MMP-3 and TNF-α in prolapse of lumbar intervertebral disc degenerative tissue[J];全科医学临床与教育;2013-01
2 WANG Yin-he,WANG Bin,YU Yang,ZHU Ze-zhang,ZHU Li-hua,QIU Yong(Dept.of Orthopaedics,The Affiliated Drum Tower Hospital of Medical College,Nanjing University,Nanjing 210008,China);Efficacy Observation of Diosmin Tablets in the Treatment of Lubar Intervertebral Disc Protrusion[J];中国药房;2012-48
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Cao Jin;Hu Fenggen;Wang Dayong;Zhang Xuchen;Wang Ding;Department of Orthopedics,Affiliated Yuhang Hospital to Hangzhou Normal College Medical College;;Efficacy Observation of Diosmin Tablets in the Treatment of Lumbar Intervertebral Disc Protrusion in Acute Stage[J];中国药师;2014-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HUANG Guang-ping;CHEN Min;LIU Xiang-qian;Dept. of Osteology,Guangdong Provincial People's Hospital&Guangdong Academy of Medical Sciences;;Efficacy Observation of Micronized Diosmin for Degenerative Lumbar Spondylolisthesis[J];中国药房;2014-42
2 KE Chang-song;WANG Ping-xia;Yangxin People's Hospital;;Diosmin Tablets Plus Niuhuang Zhiqing Suppository for Anal Sinusitis[J];中国肛肠病杂志;2014-11
3 YANG Jing;WANG Yang;The Maternal and Child Health Hospital of Lianyungang City;;Diosmin in treating lymphedema after breast cancer operation[J];中国新药与临床杂志;2014-10
4 ZHU Ting-ting;DU Ming-luo;SU Hao-ming;YANG Lin;WEN Ai-dong;HANG Tai-jun;Department of Pharmaceutical Analysis,China Pharmaceutical University;National Drug Clinical Research Base,Xijing Hospital Affiliate to the Fourth Military Medical University;;Pharmacokinetics of diosmin tablets in healthy volunteers[J];中国新药杂志;2014-14
5 WANG Yutao;SONG Xiaoyong;Department of Pharmacy,Huaihe Hospital Affiliated to Henan University;;Influence of Diosmin on the Deep Venous Thrombosis and Blood Coagulation during Peri-operative Period in Patients with Fracture[J];实用临床医药杂志;2014-13
6 Ying Jiangwei;Zhu Jinde;Department of Surgery,Second People' Hospital of Jinyun;Department of General Surgery,Lishui Central Hospital;;Effect of Diosmin and Musk Hemorrhoids Ointment on Pain and Quality of Life in Patients with Hemorrhoids[J];药物流行病学杂志;2014-06
7 ;A clinical analysis of treating pelvic hematocele syndrome with Yiqi Xiaoyu decoction plus diosmin[J];中医临床研究;2014-16
8 Cao Jin;Hu Fenggen;Wang Dayong;Zhang Xuchen;Wang Ding;Department of Orthopedics,Affiliated Yuhang Hospital to Hangzhou Normal College Medical College;;Efficacy Observation of Diosmin Tablets in the Treatment of Lumbar Intervertebral Disc Protrusion in Acute Stage[J];中国药师;2014-06
9 CUI Gong-ting;YUAN Ming;Basic Medical College of Hebei North University;Department of Urology,309 Hospital of PLA;;Effect of diosmin on chronic nonbacterial prostatitis caused by pelvic congestion in rats[J];解放军医学杂志;2014-06
10 WANG Xiaodong;JIANG Yuanyuan;WANG Jianzhong;GAO Wenshan;Department of Orthopaedics,The Affiliated Hospital of Hebei University;Operation room,The Affiliated Hospital of Hebei University;;Analysis of therapeutic effect of diosmin plus tranexamic acid for hidden blood loss in elderly patients with intertrochanteric fracture after surgery[J];实用临床医药杂志;2013-21
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