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Acute and Chronic Toxicity Studies of Huangqi Injection in Mice and Rats

Han Rong,Zhu Lujia,Pan Jianxin,Zhang Keping (Department of Pharmacology,Medical School,Suzhou University; Suzhou Institute of China Materia Medica,Suzhou 215007)  
Objective:To study the acute and chronic Toxicity of Huangqi injection.Methods:Acute toxicity text results indicated that LD 50 was 90.39(87.57~93.31)g/kg when Huangqi was given iv,and LD 50 was 108.11(102.90~113.58)g/kg when Huangqi was given ip.Chronic toxicity studies in duration 30 days were conducted in the rats at daily dose from 6 to 33 g/kg. Results:Feeding rised and weight gain of rats were normal,indices of uric,hematology,serum biochemistry and organ coefficient were in normal range,no histological lesions were detected.Conclusion:Huangqi injection was no toxicity effects in mice and rats.
【CateGory Index】: R285
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