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《Acta Chinese Medicine and Pharmacology》 2010-05
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Effects of Psoralen on Levels of Endogenous Estrogen and Progesterone from Primary Senile Mice

BA Wen-jun,SUN Li-ping,ZHANG Qiu-ju,TANG Bing-hua(Beijing University of Chinese Medicine,Beijing 100029,China)  
Objective:To discuss the effects of Psoralen on levels of endogenous estrogen and Progesterone from Primary Senile Mice.Methods: 12 month-old Primary Senile Mice were randomly divided into five groups: Primary Senile,Premrin group,Psoralen high-dose group,Psoralen medial-dose group,Psoralen minor-dose group and the adult control group.The mice in different groups were treated for one month,seven days for one-day break.Effects of Psoralen on levels of endogenous estrogen and Progesterone from Primary Senile Mice was determined by the change of the amount of E2、P、LH、FSH,as well as changes of ovary and uterine coefficient gained from observation.Result: The uterine coefficient of mice in Premrin group was highest Ovarian coefficient,and the ficient of Primary Senile Mice was higher than Psoralen high-dose group and medial-dose group.Content of E2was found in Psoralen minor-dose group in maximum value,and E2 in Premrin group and Psoralen minor-dose was higher than Primary Senile group with Statistics significance.Content of P was found to be highest in the blood serum of high-dose group.Compared with adult group,FSH in Premrin group,Psoralen medial-dose group and minor-dose group enjoyed a lower figure.Except for Primary Senile group,all groups had a higher content of LH in blood serum than young adult group.Primary Senile group was found to have the highest FSH/LH.Conclusion: Psoralen was confirmed with the the effects on levels of endogenous estrogen and Progesterone from Primary Senile Mice,and the medial-dose group is most superior.
【Fund】: 北京中医药大学科研基金资助
【CateGory Index】: R285.5
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