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《Acta Chinese Medicine and Pharmacology》 2012-04
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Inhibition of Single Drug and Combined Drugs in Qizhu Decoction to the Proliferation of Human Gastric Cancer Cell MGC-803

WANG Mao,YE Li-hong(Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China)  
Objective:To observe the inhibition of curcumol and dioscin and their combination from Qizhu decoction to the proliferation of human gastric cancer cell MGC-803,and to investigate the active principles and anti-tumor mechanisms of Qizhu decoction.Methods:MGC-803 was treated with five dosages of curcumol and dioscin single and two dosages of the combination of curcumol and dioscin for two times at the points of 24h and 48h,and the inhibitory rate of the drugs on MGC-803 proliferation was detected by MTT assay.Results:Within a certain concentration range,both curcumol dioscin have the time-and-dose-dependent inhibitional effect on the proliferation of MGC-803,and using the combination of curcumol and dioscin has a better effect than using single of the two drugs.Conclusions:Curcumol and dioscin from the Qizhu decoction might be the active principles in inhibiting the proliferation of MGC-803.
【Fund】: 江苏省科技厅科技基础实施建设计划项目(BM2009903-KF13)
【CateGory Index】: R285.5;R735.2
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