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Correlation Research between the Product Specification and Intrinsic Quality of Scutellaria baicalensis Georgi.

LIU Ting;KONG Ming;LIU Lifang;LI Songlin;State Key Laboratory of Natural Medicines,China Pharmaceutical University;Department of Metabolomics,Jiangsu Province Academy of TCM and Jiangsu Branch of China Academy of Chinese Medical Sciences;Department of Pharmaceutical Analysis,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine to Nanjing University of Chinese Medicine;  
Objective: To determine the corrlelation between different specifications and the main chemical components of Scutellaria baicalensis Georgi.( SBG). Methods: HPLC method was adopted to simultaneously determine the contents of baicalin,wogonoside,baicalein,wogonin,chrysin,oroxylin-A,schaftoside,apigenin and acteoside. The analysis was performed on a Altima TMC18 column( 4. 6 mm × 250 mm,5 μm) with a gradient mobile phase of acetonitrile-0. 1%phosphoric acid solution system at the flow rate of 1. 0 m L/min. The detective wavelength was set at 280 nm. Results:There were differences in the content of each index of first and second grade SBG from different sources( Provinces of Hebei,Shandong and Shanxi). The contents of baicalin( 19. 39%) and wogonoside( 3. 46%) in the second grade SBG from Shandong province were the highest,compared to those of the first grade SBG from Hebei province,which were15. 95% and 2. 71% respectively. In terms of the contents of chrysin and oroxylin-A,they were the highest in the first grade SBG from Shanxi province,which were 0. 14% and 0. 21%. In terms of the contents of baicalein and wogonin,they were the lowest in the first and second grade SBG from Shandong province,which were 0. 44% and 0. 08%. Correlation analysis showed that the higher the grade of SBG was,the lower the contents of baicalin and oroxylin-A would be. Cluster analysis showed that the traditional product specifications of SBG were inconsistent with the internal quality.Conclusion: Traditional product specifications of SBG were classified by the length and thickness,which has no certain relation with chemical components and can not reflect the inherent quality of SBG. It is recommended to carry out the classification of SBG on the basis of the intrinsic quality and clinical efficacy. To improve the quality standard of SBG the appearance,internal chemical components and curative effects on the quantitative research of SBG should be combined.
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