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Study of Helical CT Virtual Endoscopy in Diagnosis of Atherosclerosis

ZHAN Song hua,MAO Xin qing,YANG Zhen yan, et al (Department of Radiology, Tongji Hospital of Tongji University, Shanghai 200065,China)  
Purpose To investigate the diagnostic value of helical CT virtual endoscopy (CTVE) for atherosclerosis (AS). Methods In order to create the animal model of atherosclerosis, 15 male New Zealand white rabbits were fed with cholesterol diet for three months. We scanned the thoracic aorta of the model rabbit of atherosclerosis after injecting the contrast agents and transferred the volume image data to the graphic workstation with a virtual endoscopy software in order to reconstruct the CTVE images. The findings of CTVE images were compared with those on pathological examination. Results The diagnostic sensitivity of the atherosclerosis using CTVE was 68.75%, specifity 71.43%, false positive ratio 28.57%, false negative ratio 31.25%, positive predictive value 73.33% and negative predictive value 66.67%, respectively. A correlation was found between the findings on the CTVE images and those at the examination of pathology ( r s =0.327, P 0.05 ). Conclusion CTVE can provide diagnostic information for the detcting atherosclerosis and serve as a noninvasive supplemental method to other diagnostic methods.
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