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《Chinese Journal of Medical Imaging Technology》 2005-04
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Perfusion imaging with multi-slice spiral CT in the differential diagnosis of lung cancer and pulmonary benign masses

WU Jian-lin *, LI Guang-jun, WANG Ke-li, LI Zhi-yong, LIU Xiao-feng (Department of Radiology, the 1st Affiliated Hospital of Dalian Medical University, Dalian 116011, China)  
Objective To evaluate the differential diagnostic ability of 16-slice sprial CT perfusion imaging between lung cancer and pulmonary benign masses. Methods A total of 34 patients with pulmonary masses were studied prospectively with GE Lightspeed Qx/i plus 16-slice helical CT using cine dynamic scan (5 mm/4 slice). Lung cancer was histologically proven in 25 cases (adenocarcinoma in 13 cases, squamous carcinoma in 12 cases), and inflammatory pseudotumor was found in 4 cases, tuberculoma in 4 cases and hamartoma in 1 case. With the CT perfusion 2-body tumor software, the parameters of CT perfusion including blood volume (BV), blood flow (BF),mean transit time (MTT) and permeability surface (PS) were analyzed. Results These parameter values in lung cancer were all higher than those in pulmonary benign masses. There were significant differences in BV, MTT and PS ( P 0.05) between the two groups, especially in BV ( P 0.01).When BV≥5 ml/100 mg was set as a diagnostic threshold, the sensitivity, specificity, positive predict values and negative predict values was 96%, 78%, 92%, and 87.5%, respectively. When PS≥25 ml/(100 mg·min) was set as a diagnostic threshold, the sensitivity, specificity, positive predict values and negative predict values was 68%, 67%, 85%, and 42%, respectively. Conclusion It is helpful to differentiate lung cancer from pulmonary benign masses with MSCT perfusion imaging.
【CateGory Index】: R734.2;R816.4
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【References】
Chinese Journal Full-text Database 10 Hits
1 CHEN Gao-hong, HU Chun-feng, CHENG Guang-jun, et al. Department of Radiology, Xuzhou Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China;Blood flow featuers of perfusion of solitary pulmonary nodule with CT and it’s clinical value[J];Chinese Journal of CT and MRI;2008-04
2 WANG Xin,YU Li-juan,LIU Rui-bao,et al.Department of PET-CT Center,Tumor Hospital of Harbin Medical University,Harbin 150081,P.R.China;Effect of Different Input Arteries on Lung Perfusion Imaging by Using CT Perfusion 3.0 Software[J];Radiologic Practice;2008-12
3 ZU De-gui,ZENG Qing-yu,HUO Jian-wei (Radiology Department of Coal General Hospital,Beijing,100028,China);The Clinical Value of 64-row Spiral CT Perfusion for Diagnosis of Pulmonary Masses[J];Computerized Tomography Theory and Applications;2009-04
4 YANG Jie,YANG Ya-ying,HAN Dan (Dept. of CT,The 1st Hospital Affiliated to Kunming Medical University,Kunming Yunnan 650032,Chian);Advancement of CT Perfusion and MRI Perfusion Imaging Research to Cervical Lymph Node Lesions[J];Journal of Kunming Medical University;2008-S1
5 YANG Zhiyun,MENG Quanfei,XU Qiaolan,et al.Department of Radiology,the Affiliated Hospital of Sun YetSen University,Guangzhou,Guangdong Province 510080,P.R.China;CT Perfusion Imaging of Cervical Lymph Nodes[J];Journal of Clinical Radiology;2007-09
6 BAI Rongjie,CHENG Xiaoguang,SHEN Baozhong,et al.Department of Radiology,Beijing Jishuitan Hospital,Beijing 100035,P.R.China;Evaluation of Microvessel Structure of Solitary Pulmonary Nodules with 64-slice Spiral CT Perfusion Imaging[J];Journal of Clinical Radiology;2008-08
7 SHAO Yan-hui,QIAN Nong,XUE Yue-jun,DAI Yi-hong (Department of Radiology,Changzhou Second Hospital Affiliated of NJMU,Changzhou 213003,China);Elementary investigation of chronic obstructive pulmonary disease with multi-slice CT per-fusion imaging[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2007-07
8 GE Ying,LI Zhi-yong,WU Jian-lin(Department of Radiology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China);CT perfusion in prognosis and evaluation of therapeutic effect of radiation therapy and chemotherapy of lung carcinoma[J];Chinese Journal of Interventional Imaging and Therapy;2009-05
9 ZHANG Xiao-jun,ZHOU Huai-qi,WANG Gang,GUO Ji-gang,XU Feng(Department of Radiology,the First Hospital of Lanzhou University,Lanzhou 730000,China);The Value of 64-slice Spiral CT Perfusion Imaging in Solitary Pulmonary Nodule[J];Journal of Practical Radiology;2008-06
10 FAN Tao,ZHANG Ning,PAN Li-bo,WEI Shuang,CAO Dong-hua,ZHANG Yi,ZHANG Xiao-yi (CT Department,the Tumor’s Hospital of Shaanxi Province,Xi’an 710061,China);Evaluation of Solitary Pulmonary Nodule with Multislice Spiral CT Perfusion Imaging[J];Journal of Practical Radiology;2008-09
【Citations】
Chinese Journal Full-text Database 5 Hits
1 LI Zhiyong,WU Jianlin,NING Dianxiu,et al.Department of Radiology,the First Affiliated Hospital,Dalian Medical University,Liaoning 116011;Preliminary application of perfusion imaging in neoplasms in the brain and body with multislice helical CT[J];Radiologic Practice;2003-04
2 Che Guowei Zhou Qinghua Tang Menglin et al Department of Thoracocardiac Sur gery,West China Hospital,Sichuan University,Chengdu;A Study on Angiogenesis and Its Clinical Significance in Lung Neoplasms[J];Chinese Journal of Clinical Oncology;2002-09
3 HAN Mingjun *, FENG Gansheng, YANG Jianyong, et al. * Department of Radiology, First Hospital, China Medical University, Shenyang 110001, China;The pulmonary artery doesn′t participate in the blood supply of lung cancer: experimental and DSA study[J];Chinese Journal of Radiology;2000-12
4 ZHAO Xin-ming, ZHOU Chun-wu, WU Ning, LUO De-hong, HUANG Yao, WANG Jian-wei, SUN Wei, LIANG Ying Department of Diagnostic Radiology,Cancer Hospital of Chinese Academy of Medical Sciences, Beijing 100021, China;Multisection dynamic CT perfusion for normal and tumorous pancreas[J];Chinese Journal of Radiology;2003-09
5 ZHAO Zhen-jun,LIANG Chang-hong,XIE Shu-fei,HE Hui,RU Guang-teng (Department of Radiology,the Guangdong Provincial People's Hospital,Guangzhou 510080,China);CT perfusion in patients with lung neoplasms[J];Chinese Journal of Medical Imaging Technology;2004-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 TAN Li-Lian1,HAN Ming-Jun1,LI Yang-Bin2, JIANG Jin-Dai2,LI Shu-Xin2,ZHOU Shao-Ping2 1.Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai,Guangdong,519000, P.R.China 2.CT Department, The Second Affiliated Hospital, Guangzhou Medical College, Guangzhou,Guangdong,510260, P.R.China;Role of 16 Slices Spiral CT Angiography with 3-Dimentional CT and CT Virtual Endoscopy in Detecting Blood Supply of Lung Carcinoma[J];Chinese Journal of Cancer;2007-01
2 Mu Haiyu Shen Chunyan Tao Meng Cancer center,the Affiliated Hospital,Armed Police for Medical College,Tianjin 300162,China;Effect of VEGF on the progression and the prognosis in lung cancer[J];Oncology Progress;2009-01
3 ;Application of muti-slice CT perfusion imaging in diagnosis and differential diagnosis for solitary pulmonary nodules[J];Journal of Jilin University(Medicine Edition);2008-05
4 MING Jian-zhong ,LI Hai-ling , ZHONG Wen-xin, MAO Wen-pin, HUANG An-rong (Department of Radiology,Nanshan Hospital,Shenzhen City 518052,China);Multi-slice spiral CT Diagnosis of peripheral small Lung Cancer(Analysis of 40 Cases)[J];Computerized Tomography Theory and Applications;2005-02
5 DENG Jia-xiu ZHANG Yong-dong FENG Feng-yin LIU Juan CHEN Yu-ying Department of Radiology,Shi Yah Hospital,Shenzhen 518108,China;A Preliminary Study of CT Perfusion Imaging and Dynamic Enhanced for Lung Nodule[J];Computerized Tomography Theory and Applications;2008-02
6 WANG Fang-jun1, CHEN Wei-chang2a, GUO Liang2b, FANG Xiang-ming2b, LIU1 Peng-fei 1.Department of of Gastroenterology, The Affiliated Jiangyin Hospital of Southeast University Medical College.Jiangyin 214400, China 2.The First Affiliated Hospital of Suzhou University.a).Department of Gastroenterology.b).Department of radiology.The First Affiliated Hospital of Suzhou University, Suzhou 215006, China;The Study to the Multisection Dynamic CT Perfusion on Normal Pancreas[J];Computerized Tomography Theory and Applications;2009-02
7 TAN Li-lian, LI Yang-bin, LI Shu-xin, JIANG Jin-dai,LI Zhi-ming,ZHOU Shao-ping. CT Room, HUANG Shi-zhang.Pathology Dept,PENG Pin-xian.Thoracic Surgery Dept, the second Affiliated Hospital of Guangzhou Medical College,Guangdong 510260, China;Quantitative study on hemodynamics of peripheral type carcinomas of lung that had a diameter ≤3 cm using dynamic and enhanced spiral CT[J];Chinese Journal of CT and MRI;2006-01
8 YAO Gang,ZHANG Shi-fu,LIU Ying. Daqing Oilfield General Hospital,Heilongjiang Province 163001,China;Clinical application of 64-slice spiral CT angiography in bronchial artery[J];Chinese Journal of CT and MRI;2008-02
9 CHEN Gao-hong, HU Chun-feng, CHENG Guang-jun, et al. Department of Radiology, Xuzhou Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China;Blood flow featuers of perfusion of solitary pulmonary nodule with CT and it’s clinical value[J];Chinese Journal of CT and MRI;2008-04
10 Jia Jiantao,Wang Qinqin,Ma LijuDepartment of Pathophysiology of Changzhi Medical College;Expression and Clinical Applicative Value of Vascular Endothelial Growth Factor in Human Lung Cancer[J];Journal of Changzhi Medical College;2007-02
China Proceedings of conference Full-text Database 2 Hits
1 Jin Chen~*,Hao Si-jie,Zhu Li,Liang Zong-hui,Ashish Maskey,Wang Jun,Fu De-liang,Ni Quan-xing *Pancreatic Disease Institute,Department of General Surgery,Huashan Hospital,Fudan University, Shanghai 200040;China;Study on 64 slice helical CT perfusion imaging of pancreatic carcinoma[A];[C];2008
2 JIN Peng, SUN Gang, YI Yu-hai, XIE Zhi-yong, ZHANG Xu-ping, LI Fan-dong (Department of Radiology, Jinan Military Command of PLA, Jinan 250031,China);Transbronchial arterial chemoembolization in the treatment of lung cancer[A];[C];2004
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 SU Yong1,2, ZHAO Chong1,2, XIE Chuan-Miao1,3, LU Li-Xia1,2, SUN Ying1,2, HAN Fei1,2, WU Hu-Bing4, CUI Nian-Ji1,2, ZENG Zong-Yuan1,5, LU Tai-Xiang1,2 1. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China 2. Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China 3. Department of Imaging and Interventional Radiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China 4. PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China 5. Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Evaluation of CT, MRI and PET-CT in Detecting Retropharyngeal Lymph Node Metastasis in Nasopharyngeal Carcinoma[J];Chinese Journal of Cancer;2006-05
2 Huang Yao Wu Ning~# Wang Xiaoyi Lin Dongmei Li Lin Wang Jianwei Department of Radiology,Cancer Hospital,CAMS & PUMC,Beijing 100021,China;Evaluation of small peripheral lung carcinomas with incremental dynamic CT:Radiologic-pathologic correlation[J];Oncology Progress;2006-02
3 Zhong-ping Chen Department of Neurosurgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P.R. China;Evidence-based Medicine and Individualized Treatment in Neuro-oncology[J];Chinese Journal of Neuro-Oncology;2006-03
4 CHEN Xiao-bai, ZHANG Ju-wu, ZHAO Li-jun, DUAN Yong-li, FU Yan .(Department of Radiology, General Hospital of Beijing, Beijing 100038, China);Diagnostic Value of Spiral CT in Lymph Node Lesions in Neck[J];Computerized Tomography Theory and Applications;2004-03
5 ;The progress of medical imaging and the impact to clinical medicine[J];Chinese Journal of CT and MRI;2003-01
6 ;Evaluation on MRI in prognosis of cerebral infarction[J];Chinese Journal of CT and MRI;2003-01
7 TAN Li-lian, LI Yang-bin, LI Shu-xin, JIANG Jin-dai,LI Zhi-ming,ZHOU Shao-ping. CT Room, HUANG Shi-zhang.Pathology Dept,PENG Pin-xian.Thoracic Surgery Dept, the second Affiliated Hospital of Guangzhou Medical College,Guangdong 510260, China;Quantitative study on hemodynamics of peripheral type carcinomas of lung that had a diameter ≤3 cm using dynamic and enhanced spiral CT[J];Chinese Journal of CT and MRI;2006-01
8 LIU Wei-jin,ZHANG Dong,YANG Chun-yan,ZOU Li-guang,LIAO Cui-wei,WANG Wen-xian,DAI Shu-hua (Department of Radiology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Correlation between perfusion image of multi-slice CT and microvessel density of lung solitary nodule or mass[J];Acta Academiae Medicinae Militaris Tertiae;2008-19
9 LIU Xiaojie *, ZHANG Weixing,GAO Guifen. *Image Department, The Third Hospital, Harbin Medical University, Harbin, Heilongjiang 150040, P.R.China;The relationship between the CT signs and p53 abnormal expression in peripheral lung cancer[J];Chinese Journal of Lung Cancer;2002-01
10 WU Jianlin, LI Wei, WANG Keli, TAN Qingwei, WANG Miaomiao, SHEN Huicong. Department of Radiology, First Hospital, Dalian Medical University, Dalian, Liaoning 116011, P.R.China;The relationship among CT appearances and dynamic enhancement and microvessel density of peripheral lung cancer[J];Chinese Journal of Lung Cancer;2003-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Fei SHAN,Zhi-yong ZHANG,Meng-su ZENG,Gang CHEN,Ya-ping JIANG Department of Radiology,Zhongshan Hospital Fudan University,Shanghai 200032,China;64-Detector Row CT Volume Lung Perfusion Study in Diagnose of SPN[J];Contemporary Medicine;2009-08
2 Wei-li WENG,Zhao-xiang YE,Run-xian BAO Key Laboratory of Cancer Prevention and Therapy,Department of Radiology,Tianjin Medical University Cancer Institute & Hospital,Tianjin 300060,China;Multi-slice Spiral Computed Tomography and Pathology Features in Solitary Bronchioloalveolar Carcinoma[J];Contemporary Medicine;2009-08
3 GUAN Jian-zhong,TIAN Jian-ming,XIAO Yi,et al.Department of Radiology,No.401 Hospital of CPLA,Qingdao 266071,P.R.China;Application of Dynamic-enhanced Multi-slice Spiral CT in Solitary Pulmonary Nodules[J];Radiologic Practice;2008-10
4 JIN Zhi-fa, LUO Liang-ping, CHEN Jin-cheng, et al. Department of Radiology, the Central Hospital of Jiangmen, Guangdong 529030, China;The application research of dynamic enhanced CT in solitary pulmonary nodule[J];Chinese Journal of CT and MRI;2009-04
5 ;The value of contrast-enhanced dynamic CT and ~(18)F-FDG PET/CT for determination of pulmonary tuberculoma activity[J];Chinese Journal of CT and MRI;2010-02
6 YANG Jie,YANG Ya-ying,HAN Dan (Dept. of CT,The 1st Hospital Affiliated to Kunming Medical University,Kunming Yunnan 650032,Chian);Advancement of CT Perfusion and MRI Perfusion Imaging Research to Cervical Lymph Node Lesions[J];Journal of Kunming Medical University;2008-S1
7 JIN Zhifa,LUO Liangping,CHEN Jincheng,et al.Department of Radiology,Jiangmen Affiliated Hospital of Sun Yat-sen University,Jiangmen,Guangdong Province 529030,P.R.China;The Study of Combination of CT Perfusion and Dynamic Contrast-enhanced CT in the Differential Diagnosis of Pulmonary Nodule or Mass[J];Journal of Clinical Radiology;2008-05
8 GE Ying, WU Jian-lin (Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian Liaoning 116011, China);Research status of MSCT perfusion in pulmonary diseases[J];Journal of China Clinic Medical Imaging;2007-09
9 XU Qiu-zhen1,TENG Gao-jun1,CHU Cheng-feng1,DENG Gang1,ZHU Xiao-li2,YANG Ming1,WU Min1(1.Department of Radiology,Zhongda Hospital,Southeast University,Nanjing 210009,China;2.Department of Respiratory,Zhongda Hospital,Southeast University,Nanjing 210009,China);Prelimary application of perfusion imaging in body tumor with 64-slice CT[J];Journal of Southeast University(Medical Science Edition);2007-06
10 WEI Song-yu,CHU Cheng-feng,YANG Ming,LIU Sheng-hua(Department of Radiology,Zhongda Hospital,Southeast University,Nanjing 210009,China);Study on the effects of ROI extractions on the measurement reproducibility of 64-slice spiral CT perfusion imaging in lung tumor[J];Journal of Southeast University(Medical Science Edition);2008-05
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 Fang Chun,Qiao Wenlon,Fang Lide,et al.Department of Radiology,Huadong Hospital,Shanghai 200040;Preliminary Study of the Blood Supply from Pulmonary Artery in Bronchogenic Cancer[J];CHINESE JOURNAL OF MEDICAL COMPUTED IMAGING;1998-01
2 Xiao Xiangsheng, Ouyang Qiang, Han Xinian, et al. Department of Radiology, Changzheng Hospital, the Second Military Medical University, Shanghai 200003;Blood supply of lung cancer and its clinical implication: a study based on digital subtraction angiography[J];CHINESE JOURNAL OF RADIOLOGY;1997-07
3 Zheng Ruheng ,Dong Yonghua ,Zhou Kangrong Department of Thoracic Surgery,Zhongshan Hospital of Shanghai Medical University, Shanghai 200032;INVESTIGATION OF BLOOD SUPPLY OF BRONCHOGENIC CARCINOMA DERIVING FROM PULMONARY ARTERY[J];CHINESE JOURNAL OF ONCOLOGY;1995-01
4 SONG Shumei, ZENG Li, WU Jian, et al. Beijing Institute for Cancer Research, Beijing Medical University, Beijing 100034;Cloning and monoclonal antibody preparation of VEGF receptor KDR extracellular Ⅴ~Ⅶ domain and KDR expression in carcinomas of different origins[J];CHINESE JOURNAL OF ONCOLOGY;1999-02
5 LIU Xiang,DAI Jian ping ( Department of Neuroradiology,Beijing Neurosurgical Institute,Beijing 100050,China);Comparison Study of Different Perfusion Parameter Maps in the Evaluation of Cerebral Ischemic Lesions[J];Chinese Journal of Medical Imaging Technology;2003-02
6 QIAN Yin feng, YU Yong qiang, ZHEN Fei qun, et al (Department of Radiology, the First Hospital, Anhui Medical University, Hefei 230022, China);Primary Extra- and Intra-axial Brain Tumors: Differentiation by Using Perfusion MR Imaging[J];Chinese Journal of Medical Imaging Technology;2003-06
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