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《Chinese Journal of Medical Imaging Technology》 2007-02
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Therapeutic effect of radiofrequency ablation in unsuitable operative small hepatocellular carcinoma

GAO Wen1*, CHEN Min-hua1, YAN Kun1, YANG Wei1, SUN Yi2, XING Bao-cai2(1.Department of Ultrasound, 2.Department of Surgery, School of Oncology, Peking University, Beijing 100036, China)  
Objective To investigate the efficacy of radiofrequency ablation (RFA) in small hepatocellular carcinoma (SHCC) which were unsuitable for surgery. Methods Fifty-three patients with HCC ≤3 cm underwent ultrasound guided RFA. The average size of tumor was 2.5 cm. At the same period, 34 patients with HCC ≤3 cm received surgical resection and were serviced as control group. The treatment efficacy and survival rate of SHCC between RFA group (n=53) and resection group (n=34) was retrospectively analyzed. Statistical methods were Kaplan-Meier and t-test and chi-square test. Results The mean survival of RFA group was (54.9±3.8) month. The overall 1, 2, 3, 4 year survival rates of SHCC in RFA group were 95.9%, 87.0%, 74.5% and 61.9%, respectively, which in resection group were 94.1%, 87.8%, 75.3% and 70.7% (P=0.743); And the disease-free survival rates in RFA group were 82.8%, 70.1% and 57.5%, respectively, which in resection group were 85.1%, 69.7% and 57.1%. There were no significant difference between the two groups. The local recurrence rate of RFA group was 4.8% (4/84 tumors). In follow-up period, Eleven and 4 patients died in RFA group and resection group, respectively, due to liver failure (or tumor progression). The complication rate in RFA group was significantly lower than that in resection group. Conclusion RFA could achieve the comparable efficacy to surgery in SHCC unsuitable for surgery. It could be used as safe and effective method to treat small HCC for its high survival rates, easy operation and mini-invasiveness.
【Fund】: 北京市重大项目培育专项基金(Z000519004031);; 首都医学发展科研基金重点学科基金资助项目(ZD199909)资助。
【CateGory Index】: R735.7
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