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《Chinese Journal of Medical Imaging Technology》 2009-02
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High concentration contrast media with low flow rate on the CTA imaging of healthy rabbits

WANG Guang-yi LIANG Chang-hong LIU Hong-jun HUANG Biao (Department of Radiology,Guangdong General Hospital,Guangdong Academy of Medical Science,Guangzhou 510080,China)  
Objective To evaluate the feasibility of high-concentration contrast media(400 mgI/ml)with low flow rate in the CTA imaging of healthy rabbits.Methods Eighteen New Zealand white rabbits were randomly separated into three groups and underwent cerebral CT perfusion imaging with protocol A(400 mgI/ml,flow rate 0.5 ml/s),protocol B (300 mgI/ml,flow rate 1.0 ml/s),protocol C(400 mgI/ml,flow rate 1.0 ml/s),respectively.The total amount of iodine for each injection was 0.5 g/kg weight.CT peak values of middle cerebral artery and the time when the artery reached the peak value(PT)of each protocol were acquired and compared statistically.Results The PT of three protocols was 5 s,5 s, 4 s respectively.The mean CT value of middle cerebral artery at peak time of group A(164.67±5.16)HU was higher than that of protocol B(163.00±7.13)HU and protocol C([193.50±5.13]HU,both P0.01),but the difference between protocol A and protocol B was not significant(P=0.63).Conclusion Cerebral CTA imaging of healthy rabbits using high- concentration contrast media with low flow rate does not affect the visualization of vessels and the perfusion parameters. With same injection rate,high-concentration contrast media may improve the visualization of vessels.
【CateGory Index】: R816.1
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