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《Chinese Journal of Medical Imaging Technology》 2009-10
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Dynamic observation of angiogenesis of the rat cerebral C6 gliomas with steady-state susceptibility contrast-enhanced MR perfusion imaging

NIU Hong-tao1,ZHANG Wen-li1,GUO Qi-yong2,YU Bing2,MA Li3(1.CT Room,the First Hospital of Qinhuangdao,Qinhuangdao 066000,China;2.Department of Radiology,3.Department of Infection,Shengjing Hospital of China Medical University,Shenyang 110004,China)  
Objective To observe changes of the structure and function of microvessels during the formation and development of the rat cerebral glioma with steady-state susceptibility contrast-enhanced MR imaging.Methods A total of 30 bearing-tumor rats were divided into 3 groups(1-week group,2-week group and 3-week group)and underwent MR examination.Blood volime(BV)and vessel size index(VSIMRI)of peripheral tumor areas,central tumor areas and normal cerebral tissue in the opposite side were measured,and compared with histologic findings.Results With time of bearing-tumor increasing,BV of central tumor area present an up-and-down curve-like change,which related to the host blood vessel regression in tumor central area,the decreasing of blood vessel density and histopathologically obvious necrosis.BV of peripheral tumor areas increased because of active blood angiogenesis in this area,while VSIMRI increased gradually,especially in the central tumor area.There was obviously correlation between the VSIMRI and VSIhisto(P0.01).Conclusion BV and VSIMRI can exactly reflect the morphology and functional information of microcirculation of tumor during the growth and development of gliomas.
【CateGory Index】: R739.4
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【References】
Chinese Journal Full-text Database 2 Hits
1 NIU Hong-tao1,ZHANG Wen-li1,GUO Qi-yong2,YU Bing2,MA Li3 (1.CT Room,the First Hospital of Qinhuangdao,Qinhuangdao 066000,China;2.Department of Radiology,3.Department of Infection,Shengjing Hospital of China Medical University,Shenyang 110004,China);Assessment of therapeutic effect of anti-angiogenesis in rat C6 glioma with steady-state susceptibility contrast-enhanced MR perfusion imaging[J];Chinese Journal of Medical Imaging Technology;2010-03
2 ZHANG Song,ZOU Li-guang,ZHANG Dong,YANG Hua,QI Yue-yong,LIANG Kai-yun(Department of Radiology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);MRI observation on lymphatic endothelial cell labeled by GoldMag and anti-podoplanin antibody in vitro[J];Chinese Journal of Medical Imaging Technology;2011-02
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1 Li Gongjie, Yang Li, Shi Xiaolin et al. 307 Hospital of PLA, Beijing 100039, China;Study of morphological characteristics of tumor microvasculature in primary hepatocellular carcinoma[J];Medical Journal of Chinese People's Liberation Army;2004-07
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【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LI Gong-jie, YANG Li, SHI Xiao-lin, LI Xiao-bin, ZHEN Xiao-ling, WANG Yue-hua. Radiology Department of 307 Hospital of PLA, Beijing 100039, China;Study of the relationship between morphological characteristics of tumor microvasculature and blood supply type of primary hepatocellular carcinoma observed under DSA[J];Journal of Interventional Radiology;2005-02
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5 NIU Hong-tao1,ZHANG Wen-li1,GUO Qi-yong2,YU Bing2,MA Li3 (1.CT Room,the First Hospital of Qinhuangdao,Qinhuangdao 066000,China;2.Department of Radiology,3.Department of Infection,Shengjing Hospital of China Medical University,Shenyang 110004,China);Assessment of therapeutic effect of anti-angiogenesis in rat C6 glioma with steady-state susceptibility contrast-enhanced MR perfusion imaging[J];Chinese Journal of Medical Imaging Technology;2010-03
【Co-references】
Chinese Journal Full-text Database 6 Hits
1 Pang Xin,Zou Liguang,Yang Hua,Zhang Hui,Shu Tongsheng,Zhang Song(Department of Radiology,Xinqiao Hospital,Third Military Medical University,Chongqing,400037,China);MRI signaling characteristics of ultra-small superparamagnetic iron oxide and GoldMag[J];Acta Academiae Medicinae Militaris Tertiae;2010-03
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3 ZHAO Jing-long~1,ZHANG Gui-xiang~(1*),HU Yun-sheng~1,LI Yu-jie~1, ZHOU Gen-quan~1,ZHANG Yue-ping~1,WU Ji-hong~2 (1.Department of Radiology,2.Central Laboratory,Shanghai Jiao Tong University Affiliated First People's Hospital,Shanghai 200080,China);DCE-MRI study on anti-angiogenic effect of rabbit VX2 tumor by antisense VEGF cDNA[J];Chinese Journal of Medical Imaging Technology;2005-11
4 SANG Li,WANG Bin,LIU Feng,NING Hou-fa,GE Yan-ming,SUN Xi-he,DONG Peng(Medical Imaging Centre,the Affiliated Hospital of Weifang Medical College,Weifang 261031,China);Diffusion weighted imaging in assessing TACE combined with anti-angiogenesis in the treatment of VX2 hepatic implantation tumor in rabbits[J];Chinese Journal of Medical Imaging Technology;2009-05
5 HAN Ming1, CHENG Xin2, ZHANG Shi-zhuang2, WANG Bin2, QU Lin-tao3(1.Department of Basic Medicine Education, Weifang Medical College, Weifang 261053, China; 2.Department of Radiology, Affiliated Hospital of Weifang Medical College, Weifang 261031, China; 3.Department of Radiology, Laiyang Center Hospital, Yantai 265200, China);Apparent diffusion coefficient in the evaluation of therapeutic effect of endostatin on colonic carcinoma in mice[J];Chinese Journal of Medical Imaging Technology;2009-06
6 QU Hai-yuan1, XU Huan2, HAN Hong-bo1, CHEN Qi2, LIU Jing1, DENG Yi-hui2, XU Ke1 (1.Department of Radiology, the First Hospital of China Medical University, Shenyang 110001, China; 2.School of Pharmacy, Shenyang Pharmaceucal University, Shenyang 110016, China);Development of α_vβ_3 integrin targeted superparamagnetic liposome and in vitro MR observation[J];Chinese Journal of Medical Imaging Technology;2009-06
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 HAO Wei,ZHANG Ying-ying,XU Rong-tian(Department of Radiology,the First Hospital of China Medical University,Shenyang 110001,China);Magnetic resonance perfusion imaging in rat models of brain edema after surgical brain injury: Analysis of the efficacy and the dose-dependent manner of aminoguanidine[J];Chinese Journal of Medical Imaging Technology;2011-03
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