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Dynamic observation of angiogenesis of the rat cerebral C6 gliomas with steady-state susceptibility contrast-enhanced MR perfusion imaging

NIU Hong-tao1,ZHANG Wen-li1,GUO Qi-yong2,YU Bing2,MA Li3(1.CT Room,the First Hospital of Qinhuangdao,Qinhuangdao 066000,China;2.Department of Radiology,3.Department of Infection,Shengjing Hospital of China Medical University,Shenyang 110004,China)  
Objective To observe changes of the structure and function of microvessels during the formation and development of the rat cerebral glioma with steady-state susceptibility contrast-enhanced MR imaging.Methods A total of 30 bearing-tumor rats were divided into 3 groups(1-week group,2-week group and 3-week group)and underwent MR examination.Blood volime(BV)and vessel size index(VSIMRI)of peripheral tumor areas,central tumor areas and normal cerebral tissue in the opposite side were measured,and compared with histologic findings.Results With time of bearing-tumor increasing,BV of central tumor area present an up-and-down curve-like change,which related to the host blood vessel regression in tumor central area,the decreasing of blood vessel density and histopathologically obvious necrosis.BV of peripheral tumor areas increased because of active blood angiogenesis in this area,while VSIMRI increased gradually,especially in the central tumor area.There was obviously correlation between the VSIMRI and VSIhisto(P0.01).Conclusion BV and VSIMRI can exactly reflect the morphology and functional information of microcirculation of tumor during the growth and development of gliomas.
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