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《TRADITIONAL CHINESE DRUG RESEARCH & CLINICAL PHARMACOLOGY》 2000-02
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Improvement Effect of Bajishin on Spatial Learning and Memory Abiligy of Rats

Tan BaoXuan,Su wen,Chen Jiewen (Department of Physiology,Guangzhou University of TCM,Guangzhou 510405)  
Senile rat model was induced by D_Galactose.The effect of Bajishin on spatial learning and memory ability of senile rats was observed by Morris Water Maze test and the effect of Bajishin on the long_term potentiation(LTP)of hippocampus synapse was observed by hippocampal slice perfusion technique.The results showed that the escape latency of senile rats was shortened,the proplateau quadrant and the 40cm circle swimming times lengthened,the proplateau quadrant swimming path percentage increased and the LTP effect of hippocampal slice increased significantly with an dose/effect relationship.It is suggested that Bajishin can improve spatial learning and memory ability of senily rats,and its mechanism may relate to the increase of LTP effect of hippocampal synapse transmission.
【Fund】: 国家中医药管理局课题 !(97L025)
【CateGory Index】: R285.5
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