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《Traditional Chinese Drug Research & Clinical Pharmacology》 2007-05
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Effect of Baicalin on Renal Function in Diabetic Nephropathy Rats and Its Anti-oxidative Action

SU Ning1,LUO Rongjing1,SU Hang2,LUO Hui1,LANG Jianying1,NONG Hui1,LI Li1 (1.Basic Medical College,Guangzhou University of TCM,Guangzhou 510006;2. Dept. of Clinical Molecular Medicine,the Second Affiliated Hospital of Guangzhou Medical College,Guangzhou 510260)  
Objective To explore the effects of baicalin (Bai) on renal function of diabetic nephropathy (DN) rats and on the antioxigenic enzymes levels of actien mechanism. Methods DN rat model was established by one-dose intraperitoneal injection of streptozotocin. Six weeks after injection with baicalin into the abdominal cavity of DN rats,renal index was caculated,24-hour urine was gathered and microprotein content was measured,one kidney was used for morphological examination under electron microscope,and the other one was used to make homogenate for measuring the SOD and GSH-PX activities. A normal control group was also established at the same time. Results Microprotein in the urine of baicalin group was significantly decreased,and there was significant difference between this group and the model control group (P 0.05);Renal tissue observation showed that glomerular basement membrane in the baicalin group was much thinner than that in the model group,and there was less extracellular matrix (ECM) deposit in the mesangial area,less edema in the epithelial cells of renal tubule;There was significant difference of SOD activity between the baicalin group and the model group (P 0.05);GSH-PX activity in the baicalin group was higher than those in the model group,but the difference was insignificant (P 0.05). Conclusion Baicalin can decrease urine protein in DN rats and ECM deposit in the kidney,and delay the development progress of DN. Its mechanism is probably related to the increase of antioxigenic function of the kidney.
【Fund】: 广州省中医药管理局课题(103031)
【CateGory Index】: R285.5
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