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Analgesic and Anti-inflammation Effect of Borneol

SUN Xiaoping,OU Lijuan,MI Suiqing,WANG Ningsheng (Institute of Clinic Pharmacology Research,Guangzhou University of TCM,Guangzhou 510405)  
Objective To observe the analgesic action and anti-inflammation effect of borneol. Methods The analgesic action and anti-inflammation effect of borneol were observed by mouse hot-plate test,mouse acetic-acid-induced twisting test,mouse abdominal cavity capillary permeability increase test induced by acetic acid,and rat pedal swelling test induced by carrageenin. Results Borneol reduced the pedal swelling of rats,ED50=0.3242 g·kg-1,increased pain threshold in mice ED50=0.3870 g·kg-1,inhibited twisting response of mice obviously,ED50=0.5813 g·kg-1. In the same dose,the analgesic action of borneol was stronger than the anti-inflammatory effect. Conclusion Borneol has certain analgesic action and anti-inflammation effect.
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