Therapeutic Effects of Cordyceps Polysaccharide on Adenine-induced Chronic Renal Failure in Rats
YIN Hongping1, LV Xiaobo2, CHEN Tao1(1. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009; 2. School of Pharmacy, Nanjing University of TCM, Nanjing 210046)
Objective To study the therapeutic effects of Cordyceps polysaccharide (CP) on adenine-induced chronic renal failure(CRF)in rats. Methods CRF model was induced by Adenine ig .The rats were randomized into normal group, model group, CP high, moderate, Low-dosage groups and Dexamethasone group. The models of adenine-induced nephrosis were established by intragastric administration of adenine 300 mg/kg for 21 days. After treatment, renal function, biochemical indicators, kidney index, renal pathologic changes and serum TNF-α were observed. Results Compared with the model group, the degree injury of renal function in CP groups was palliated significant, renal pathologic changes were palliated significant, renal index and content of serum TNF-α were both decreased significant. Conclusion CP has a therapeutic and preventive effect on adenine-induced CRF, and can prevent the generation and development of CRF, improve renal function.