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《Traditional Chinese Drug Research & Clinical Pharmacology》 2009-03
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Therapeutic Effects of Cordyceps Polysaccharide on Chronic Renal Failure Rats Induced by 5/6 Nephrectomy

CHEN Tao1,YIN Hongping2,LV Xiaobo1,LI Haitao1(1.School of Pharmacy,Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China;2.School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China)  
Objective To study the therapeutic effects of Cordyceps polysaccharide(CP)on chronic reanl failure(CRF) Rats.Methods CRF rat model was estblished by 5/6 nephrectomy.After the modeling,sixty adult SD rats were randomly divided into 6 groups:positive control group(receiving 0.1 mg/kg dexamethasone,im),high-,middle-and low-dose CP groups(gavage of CP at the dose of 160,80 and 40 mg/kg,respectively),sham-operation group(gavage of normal saline at the same volume of CP) and the model group(gavage of normal saline at the same volume of CP).After treatment for 14 days,biochemical indicator,renal function,and renal pathologic changes were observed.Results Compared with the model group,serum urea nitrogen,serum creatinine,urinary protein and urine volume were decreased in the positive control group and CP groups(P 0.01or P 0.05),and the decrease of the above indexes was obvious in high-and middle-dose CP groups compared with the positive control group.Renal pathological injuries were significantly relieved in the positive control group and high-dose CP group,and somewhat relieved in middle-and low-dose CP groups.Conclusion Cordyceps polysaccharide has an effect on treating chronic renal failure rats Induced by 5/6 nephrectomy,and can improve the renal function.
【CateGory Index】: R285.5
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